Blahos J, Svoboda Z, Höschl C
Endokrinologie. 1976;68(2):226-30.
The authors have studied the effect of calcitonin on glucose metabolism. Ten healthy volunteers were investigated. Calcitonin administered intramuscularly in one single dose inhibited the physiological decrease of blood glucose levels during the forenoon fast. Salmon calcitonin administered in an intravenous infusion in the dose of 0.15 U MRC/kg of body weight impaired the glucose tolerance test with the increase of blood glucose levels. The greatest difference was in the 120th minute after the administration of 100 gm of glucose. Calcitonin failed to produce any significant inhibition of immunoreactive insulin release following the glucose stimulus. However, further studies will be necessary to show whether this lack of the inhibitory beta cytotropic action of calcitonin was due to the low dose of calcitonin.
作者们研究了降钙素对葡萄糖代谢的影响。对10名健康志愿者进行了调查。单次肌肉注射降钙素抑制了上午禁食期间血糖水平的生理性下降。以0.15 U MRC/千克体重的剂量静脉输注鲑鱼降钙素，随着血糖水平的升高，损害了葡萄糖耐量试验。给予100克葡萄糖后120分钟时差异最大。降钙素未能对葡萄糖刺激后免疫反应性胰岛素的释放产生任何显著抑制作用。然而，是否降钙素缺乏这种抑制性β细胞促生长作用是由于降钙素剂量较低，还需要进一步研究。
