他莫昔芬诱导的肺损伤。
Tamoxifen-induced Lung Injury.
作者信息
Etori Satoshi, Nakano Ryoji, Kamada Hideki, Hosokawa Keisuke, Takeda Shinichi, Fukuhara Masanori, Kenmotsu Yoshiyuki, Ishimine Atsushi, Sato Kumiko
机构信息
Department of Respiratory Medicine, Kin-i-Kyo Chuo Hospital, Japan.
Department of Surgery, Kin-i-Kyo Chuo Hospital, Japan.
出版信息
Intern Med. 2017 Nov 1;56(21):2903-2906. doi: 10.2169/internalmedicine.8649-16. Epub 2017 Sep 25.
Cases of drug-induced lung injury caused by tamoxifen are rare. A 74-year-old man underwent surgery for the treatment of right breast cancer; tamoxifen was administered as an adjuvant therapy after surgery. The patient developed cough and dyspnea and chest computed tomography showed ground glass opacification in the lower lobe of the right lung. He was diagnosed with tamoxifen-induced lung injury. The diagnosis was made based on the exclusion of other causes and recurrence with the re-administration of tamoxifen. Physicians should therefore be aware of the potential for the development of tamoxifen-induced lung injury.
由他莫昔芬引起的药物性肺损伤病例罕见。一名74岁男性因治疗右乳腺癌接受手术；术后给予他莫昔芬作为辅助治疗。患者出现咳嗽、呼吸困难，胸部计算机断层扫描显示右肺下叶磨玻璃样混浊。他被诊断为他莫昔芬所致的肺损伤。该诊断是在排除其他病因并再次服用他莫昔芬后复发的基础上做出的。因此，医生应意识到他莫昔芬所致肺损伤发生的可能性。
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