天然物质在人肝细胞癌中的协同抗癌活性
Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma.
作者信息
Kojima-Yuasa Akiko, Huang Xuedan, Matsui-Yuasa Isao
机构信息
Department of Food and Human Health Sciences, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
Department of Pharmacognosy, School of Pharmacy, Kitasato University, 5-9-1 Shirogane, Minato-ku, Tokyo 108-8641, Japan.
出版信息
Diseases. 2015 Oct 22;3(4):260-281. doi: 10.3390/diseases3040260.
Hepatocellular carcinoma (HCC) is highly resistant to currently available chemotherapeutic agents. The clinical outcome of HCC treatment remains unsatisfactory. Therefore, new effective and well-tolerated therapy strategies are needed. Natural products are excellent sources for the development of new medications for disease treatment. Recently, we and other researchers have suggested that the combined effect of natural products may improve the effect of chemotherapy treatments against the proliferation of cancer cells. In addition, many combination treatments with natural products augmented intracellular reactive oxygen species (ROS). In this review we will demonstrate the synergistic anticancer effects of a combination of natural products with chemotherapeutic agents or natural products against human HCC and provide new insight into the development of novel combination therapies against HCC.
肝细胞癌（HCC）对目前可用的化疗药物具有高度抗性。HCC治疗的临床结果仍不尽人意。因此，需要新的有效且耐受性良好的治疗策略。天然产物是开发用于疾病治疗的新药物的优良来源。最近，我们和其他研究人员表明，天然产物的联合作用可能会提高化疗对癌细胞增殖的治疗效果。此外，许多天然产物联合治疗可增加细胞内活性氧（ROS）。在本综述中，我们将展示天然产物与化疗药物或天然产物联合对人HCC的协同抗癌作用，并为开发针对HCC的新型联合疗法提供新的见解。
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