Department of Pharmacology, Animal Physiology, Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, Student Campus, 6000 Stara Zagora, Bulgaria.
Department of Medical Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 "Armeyska" St., 6000 Stara Zagora, Bulgaria.
Int J Mol Sci. 2023 Aug 11;24(16):12705. doi: 10.3390/ijms241612705.
Several phytochemicals, which display antioxidant activity and inhibit cancer cell phenotypes, could be used for cancer treatment and prevention. Lignin, as a part of plant biomass, is the second most abundant natural biopolymer worldwide, and represents approximately 30% of the total organic carbon content of the biosphere. Historically, lignin-based products have been viewed as waste materials of limited industrial usefulness, but modern technologies highlight the applicability of lignin in a variety of industrial branches, including biomedicine. The aims of our preliminary study were to compare the antioxidant properties of water-soluble alkali lignin solutions, before and after UV-B irradiation, as well as to clarify their effect on colon cancer cell viability (Colon 26), applied at low (tolerable) concentrations. The results showed a high antioxidant capacity of lignin solutions, compared to a water-soluble control antioxidant standard (Trolox) and remarkable radical scavenging activity was observed after their UV-B irradiation. Diminishment of cell viability as well as inhibition of the proliferative activity of the colon cancer cell line with an increase in alkali lignin concentrations were observed. Our results confirmed that, due to its biodegradable and biocompatible nature, lignin could be a potential agent for cancer therapy, especially in nanomedicine as a drug delivery system.
几种具有抗氧化活性并能抑制癌细胞表型的植物化学物质可用于癌症的治疗和预防。木质素作为植物生物质的一部分，是全球第二丰富的天然生物聚合物，约占生物圈总有机碳含量的 30%。从历史上看，木质素基产品一直被视为工业用途有限的废物材料，但现代技术强调了木质素在包括生物医学在内的各种工业领域的适用性。我们初步研究的目的是比较水可溶性碱木质素溶液在 UV-B 照射前后的抗氧化特性，并阐明其在低（可耐受）浓度下对结肠癌细胞活力（Colon 26）的影响。结果表明，木质素溶液具有很高的抗氧化能力，与水溶性对照抗氧化标准（Trolox）相比，并且在 UV-B 照射后观察到其具有显著的自由基清除活性。随着碱木质素浓度的增加，观察到细胞活力降低以及结肠癌细胞系增殖活性的抑制。我们的研究结果证实，由于其可生物降解和生物相容性，木质素可能是癌症治疗的潜在药物，特别是在纳米医学中作为药物输送系统。
