谷胱甘肽-S-转移酶家族基因在男性不育中的作用。
Role of Glutathione-S-Transferase Family Genes in Male Infertility.
作者信息
Kolesnikova L I, Kurashova N A, Bairova T A, Dolgikh M I, Ershova O A, Dashiev B G, Korytov L I, Koroleva N V
机构信息
Research Center of Family Health and Human Reproduction Problems, Irkutsk, Russia.
Republican Perinatal Center, Ulan-Ude, Republic of Buryatia, Russia.
出版信息
Bull Exp Biol Med. 2017 Sep;163(5):643-645. doi: 10.1007/s10517-017-3869-9. Epub 2017 Sep 25.
Polymorphisms of xenobiotic detoxification genes GSTT1 and GSTM1 and activity of glutathione system enzymes were studied in men with infertility. The frequency of deletion variant of GSTT1 gene in men with infertility was by 2 times higher than in fertile men. Deletion variant of GSTM1 gene was 1.4-fold more frequent in infertile men than in fertile men. Complete deletion of two genes was found in 19% men with infertility and only in 6% fertile men. The balance of activity of glutathione system enzymes essential for the effective detoxification of exogenous xenobiotics and toxic endogenous metabolites was impaired in infertile carriers of deletion variants of genes. Our results suggest that adaptation mechanisms are disordered in infertile men.
在不育男性中研究了外源性解毒基因GSTT1和GSTM1的多态性以及谷胱甘肽系统酶的活性。不育男性中GSTT1基因缺失变异的频率比生育能力正常的男性高2倍。不育男性中GSTM1基因缺失变异的频率比生育能力正常的男性高1.4倍。在19%的不育男性中发现两个基因完全缺失，而在生育能力正常的男性中仅为6%。对于外源性异生物和有毒内源性代谢产物的有效解毒至关重要的谷胱甘肽系统酶活性平衡，在基因缺失变异的不育携带者中受到损害。我们的结果表明，不育男性的适应机制紊乱。
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