来自绿指软珊瑚的一种新的多拉贝拉烷二萜和一种新的聚乙炔。
A new dolabellane diterpene and a new polyacetylene from the soft coral Clavularia viridis.
作者信息
Zhao Ming, He Tao, Shi Shao-Kui, Song Ling-Xiang, Lu Yu
机构信息
a Department of Pharmacy , Xuyi People's Hospital , Xuyi , P.R. China.
b Department of Clinical Research Center , Xuyi People's Hospital , Xuyi , P.R. China.
出版信息
Nat Prod Res. 2018 May;32(9):1104-1108. doi: 10.1080/14786419.2017.1380025. Epub 2017 Sep 25.
A new dolabellane diterpene (1) and a new polyacetylene (2) were isolated from the soft coral Clavularia viridis. The structures of 1 and 2 were elucidated by spectroscopic analyses including 1D and 2DNMR experiments and HRESIMS data. The absolute configuration of 1 was determined by the modified Mosher's method and 2 by ECD calculations. Compound 1 exhibited moderate cytotoxicities against MCF-7 and A549 cell lines with IC values of 10.5 and 12.6 µM, respectively.
从软珊瑚绿指形软珊瑚（Clavularia viridis）中分离出一种新的多拉贝拉烷二萜（1）和一种新的聚乙炔（2）。通过包括一维和二维核磁共振实验以及高分辨电喷雾电离质谱数据在内的光谱分析阐明了1和2的结构。通过改良的莫舍尔方法确定了1的绝对构型，通过电子圆二色性计算确定了2的绝对构型。化合物1对MCF-7和A549细胞系表现出中等细胞毒性，IC值分别为10.5和12.6 µM。
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