Basat Sema, Sivritepe Rıdvan, Ortaboz Damla, Sevim Çalık Ecem, Küçük Eyüp Veli, Şimşek Berkan, Atay Sabri, Çalışgan Arzu
a Department of Internal Medicine , University of Health Sciences Umraniye Education and Research Hospital , İstanbul , Turkey.
b Department of Urology , University of Health Sciences Umraniye Education and Research Hospital , İstanbul , Turkey.
Aging Male. 2018 Jun;21(2):111-115. doi: 10.1080/13685538.2017.1379488. Epub 2017 Sep 23.
Recent studies have suggested that a relationship could exist between 25-hydroxyvitamin D [25(OH)D] deficiency and erectile dysfunction (ED). The present study evaluated the relationship between 25(OH)D levels and ED in male patients with type 2 diabetes mellitus (DM). The study included 98 patients with type 2 DM aged between 18-80 years. The International Index of Erectile Function (IIEF-5) Questionnaire was administered. The patients were divided into three groups according to IIEF-5 scoring: IIEF-5 score between 5-10, severe ED; IIEF-5 score between 11-20, moderate ED; IIEF-5 score between 21-25, no ED. Biochemical parameters, 25(OH)D and hormonal analysis tests were obtained in all patients. All parameters were compared between these three groups. Of 98 patients included in the study, 32 had severe ED, 45 had moderate ED and 21 had no ED. The mean age was 55.12 ± 9.39 years and the mean 25(OH)D level was 13.69 ± 8.15 ng/ml. When the three groups were compared, 25(OH)D levels were significantly lower in patients with the IIEF-5 score between 5-10 (p = 0.020). There was a moderate positive relationship between IIEF-5 score and 25(OH)D level (r = 0.21, p = 0.038). The patients with severe ED have considerably lower 25(OH)D levels.
近期研究表明，25-羟维生素D[25(OH)D]缺乏与勃起功能障碍（ED）之间可能存在关联。本研究评估了2型糖尿病（DM）男性患者的25(OH)D水平与ED之间的关系。该研究纳入了98例年龄在18至80岁之间的2型DM患者。采用国际勃起功能指数（IIEF-5）问卷进行评估。根据IIEF-5评分将患者分为三组：IIEF-5评分在5至10分之间，为重度ED；IIEF-5评分在11至20分之间，为中度ED；IIEF-5评分在21至25分之间，为无ED。对所有患者进行生化参数、25(OH)D及激素分析检测。对这三组之间的所有参数进行比较。在纳入研究的98例患者中，32例患有重度ED，45例患有中度ED，21例无ED。平均年龄为55.12±9.39岁，平均25(OH)D水平为13.69±8.15 ng/ml。比较三组时，IIEF-5评分在5至10分之间的患者25(OH)D水平显著较低（p = 0.020）。IIEF-5评分与25(OH)D水平之间存在中度正相关（r = 0.21，p = 0.038）。重度ED患者的25(OH)D水平明显较低。
