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勃起功能障碍严重程度、平均血小板体积与维生素 D 水平之间的关系。

The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels.

机构信息

Department of Urology, University of Health Sciences, Okmeydani Training & Research Hospital, Istanbul, Turkey.

出版信息

Aging Male. 2020 Sep;23(3):173-178. doi: 10.1080/13685538.2018.1459544. Epub 2018 Apr 4.

DOI:10.1080/13685538.2018.1459544
PMID:29616850
Abstract

The aim of this study was to evaluate the relationship between mean platelet volume (MPV) and vitamin D levels according to ED severity. Between October 2015 and September 2017, patients who applied to the andrology outpatient clinic with an ED complaint were retrospectively reviewed. Patients with diabetes, hypertension, hyperlipidemia, malignancy, late-onset hypogonadism and smokers were not included in the study. The International Erectile Function Index-Erectile Function (IIEF-EF) questionnaire was used to assess the levels of erectile function. According to this scoring system, patients were divided into two groups. IIEF score: between 17 and 25 = mild ED (Group 1) and IIEF score between 16 and 0 = moderate-severe ED (Group 2). Blood samples of the patients were taken from antecubital vein and MPV and 25-hydroxyvitamin D [25(OH)D] levels were evaluated. Ninety patients were included in the study (Group 1:  = 41, Group 2:  = 49). The mean age of the patients was 41.07 ± 8.56 and the mean body mass index (BMI) was 27.59 ± 3.91. 25(OH)D levels were found to be statistically lower in Group 2 (18.85 ± 6.09; 13.98 ± 7.10;  = .001). MPV levels were found to be statistically higher in Group 2 (10.05 ± 0.81; 10.78 ± 1.16;  = .001). Correlation between IIEF-EF scores and 25(OH)D levels was positive ( = .03,  = 0.22). There was negative correlation between IIEF-EF scores and MPV and between 25(OH)D levels and MPV levels [ = .003 for IIEF-EF/MPV,  = .04,  = -0.23 for 25(OH)D/MPV]. There is a significant positive correlation between ED severity and 25(OH)D levels and there is a significant negative correlation between ED severity and MPV levels.

摘要

本研究旨在评估平均血小板体积 (MPV) 与维生素 D 水平之间的关系,并根据 ED 的严重程度进行评估。2015 年 10 月至 2017 年 9 月,回顾性分析因 ED 症状就诊于男科门诊的患者。排除患有糖尿病、高血压、高脂血症、恶性肿瘤、迟发性性腺功能减退症和吸烟者的患者。采用国际勃起功能指数-勃起功能(IIEF-EF)问卷评估勃起功能水平。根据该评分系统,患者分为两组。IIEF 评分:17-25=轻度 ED(组 1),IIEF 评分 16-0=中度-重度 ED(组 2)。从肘前静脉采集患者的血液样本,评估血小板体积 (MPV) 和 25-羟维生素 D [25(OH)D] 水平。本研究共纳入 90 例患者(组 1:n=41,组 2:n=49)。患者的平均年龄为 41.07±8.56 岁,平均体重指数(BMI)为 27.59±3.91。结果发现,组 2 的 25(OH)D 水平明显较低(18.85±6.09;13.98±7.10;=0.001)。组 2 的 MPV 水平明显较高(10.05±0.81;10.78±1.16;=0.001)。IIEF-EF 评分与 25(OH)D 水平呈正相关(=0.03,=0.22)。IIEF-EF 评分与 MPV 之间呈负相关,25(OH)D 水平与 MPV 水平之间呈负相关[IIEF-EF/MPV:=0.003,=0.04,=0.23]。ED 严重程度与 25(OH)D 水平呈显著正相关,与 MPV 水平呈显著负相关。

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Front Endocrinol (Lausanne). 2022 Oct 6;13:1027430. doi: 10.3389/fendo.2022.1027430. eCollection 2022.
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J Clin Med. 2020 Aug 4;9(8):2513. doi: 10.3390/jcm9082513.
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