Imhof P R, Müller P, Keller R
Medical Department, Ciba-Geigy, Ltd., Basle, Switzerland.
Methods Find Exp Clin Pharmacol. 1987 Dec;9(12):829-32.
In a placebo-controlled study the hemodynamic effects of single doses of oxprenolol, metoprolol, prenalterol, phentolamine, nifedipine, nitroglycerin, angiotensin II and frusemide have been investigated in 9 healthy volunteers by means of the combined measurement of heart rate, blood pressure, pre-ejection period (systolic time intervals) and stroke volume (impedance cardiography) in the supine and tilted positions (70 degrees). Each cardiovascular agent exhibited its characteristic pharmacodynamic profile, which allowed a clear-cut discrimination. The effects of oxprenolol and metoprolol, however, could not be distinguished by this procedure. The pre-ejection period, although not a very specific parameter, proved to be most sensitive to the pharmacological interventions, whereas stroke volume was less often influenced. It is concluded that the proposed selection of non-invasive parameters is a very suitable and simple means for early cardiovascular drug testing in man.
在一项安慰剂对照研究中，通过在仰卧位和倾斜70度体位下联合测量心率、血压、射血前期（收缩期时间间期）和每搏输出量（阻抗心动图），对9名健康志愿者单剂量服用氧烯洛尔、美托洛尔、普瑞特罗、酚妥拉明、硝苯地平、硝酸甘油、血管紧张素II和呋塞米的血流动力学效应进行了研究。每种心血管药物都呈现出其特征性的药效学特征，这使得能够进行明确区分。然而，通过该程序无法区分氧烯洛尔和美托洛尔的效应。射血前期虽然不是一个非常特异的参数，但被证明对药理干预最为敏感，而每搏输出量受影响的情况较少。结论是，所提出的非侵入性参数选择是人体早期心血管药物测试的一种非常合适且简单的方法。
