Tan L B, Bryant S, Murray R G
Cardiac Department, John Radcliffe Hospital, Oxford.
Lancet. 1988 Mar 12;1(8585):560-1. doi: 10.1016/s0140-6736(88)91354-2.
The haemodynamic effects of intravenous cyclizine, an antiemetic that is widely given with opioids in left ventricular failure and myocardial infarction, were studied in 11 patients with severe heart failure. Cyclizine significantly increased systemic and pulmonary arterial pressures, and right and left ventricular filling pressures, and negated the venodilatory effects of diamorphine. The use of cyclizine in patients with heart failure should, therefore, be avoided.
在11例严重心力衰竭患者中，研究了静脉注射赛克利嗪（一种在左心室衰竭和心肌梗死中广泛与阿片类药物联用的止吐药）的血流动力学效应。赛克利嗪显著升高了体循环和肺动脉压、左右心室充盈压，并抵消了二醋吗啡的静脉扩张作用。因此，心力衰竭患者应避免使用赛克利嗪。
