Wang Gui-Qian, Xie Yan-Ming, Liu Huan, Zhang Yin, Jia Ping-Ping, Zhuang Yan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Statistical Institute of Renmin University of China, Beijing 100872, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jan;42(1):175-181. doi: 10.19540/j.cnki.cjcmm.20161222.027.
To explore the real world clinical medication and combination characteristics of Shenxiong glucose injection. The basic information of patients with Shenxiong glucose injection, traditional Chinese and western medicine diagnosis information, doctor advice information and laboratory test information from the hospital information system(HIS) of 19 tertiary hospitals in China. Apriori algorithm was adopted to establish the models, and Clementine 12.0 was used for correlation analysis to analyze the real world clinical medication and combination characteristics of Shenxiong glucose injection. Among 8 316 patients in the study, 523 kinds of western medicine and 148 kinds of traditional Chinese medicine(TCM) were used. In combined application, the single western medicine with highest use frequency was aspirin(1 908 cases, 22.94%), and single Chinese medicine with highest use frequency was Shuxuetong injection (771 cases, 9.27%); the most common TCM pair was Xianling Gubao capsule+Lugua Duotai injection(rules support degree was 2.55%), and the most common western medicine pair was aspirin+atorvastatin(degree of association rules was 10.15%). They were often used in combination with antibiotics, blood-activating and stasis-dissolving prescription, and adrenal cortical hormone drugs. Shenxiong glucose injection was often used in combination with antiplatelet drugs and blood-activating and stasis-dissolving prescription in clinical application to enhance the effects of anti-platelet aggregation and blood-activating and stasis-dissolving; it was often used in combination with antibiotics to treat cor pulmonale, and incompatibility shall be noticed to ensure efficacy enhancement under the premise of clinical medication safety.
探讨参芎葡萄糖注射液的真实世界临床用药及联合用药特点。收集中国19家三级医院医院信息系统（HIS）中使用参芎葡萄糖注射液患者的基本信息、中西医诊断信息、医嘱信息及实验室检查信息。采用Apriori算法建立模型，运用Clementine 12.0进行关联分析，以分析参芎葡萄糖注射液的真实世界临床用药及联合用药特点。研究的8316例患者中，使用西药523种，使用中药148种。联合用药方面，使用频率最高的单一西药是阿司匹林（1908例，22.94%），使用频率最高的单一中药是舒血宁注射液（771例，9.27%）；最常见的中药药对是仙灵骨葆胶囊 + 鹿瓜多肽注射液（规则支持度为2.55%），最常见的西药药对是阿司匹林 + 阿托伐他汀（关联规则度为10.15%）。它们常与抗生素、活血化瘀方剂及肾上腺皮质激素类药物联合使用。参芎葡萄糖注射液临床应用中常与抗血小板药物及活血化瘀方剂联合使用，以增强抗血小板聚集及活血化瘀效果；常与抗生素联合用于治疗肺心病，临床用药时应注意配伍禁忌，确保在用药安全前提下提高疗效。
