Guo Xiao-Chen, Gao Yang, Xie Yan-Ming, Sun Lin-Xi, Xu Hong-Yan, Zhuang Yan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2020 Jul;45(14):3307-3315. doi: 10.19540/j.cnki.cjcmm.20200327.501.
In this study, the clinical characteristics and drug combination rules of Danshen Chuanxiongqin Injection in the treatment of patients with cerebral infarction were analyzed. The inpatient information of 2 857 patients of cerebral infarction treated with Danshen Chuanxiongqin Injection in HIS database of 20 grade Ⅲ class A hospitals in China was collected, and a model was established by description analysis and Apriori algorithm, in order to explore the clinical characteristics and drug combination rules of Danshen Chuan-xiongqin Injection in the treatment of cerebral infarction. The results showed that among patients of cerebral infarction treated with Danshen Chuanxiongqin Injection, 1 727 patients were older than 65 years old, accounting for 69.61%, and 1 610 were males, accounting for 63.59%. Commonly used drugs included lipid-lowering agents, anticoagulant thrombolytic agents, antiplatelet agents, stimulants of brain metabolism, vasodilators and other Western drugs, as well as traditional Chinese medicines, such as blood-activating agents, heat-clearing agents and expectorant agents. The Western medicine with the highest use frequency in combination with Danshen Chuan-xiongqin Injection was aspirin enteric-coated tablets(1 528 cases, 53.48%). The traditional Chinese medicine with the highest use frequency in combination with Danshen Chuanxiongqin Injection was Xingnaojing Injection, with a total of 378 cases, accounting for 13.23%. Among them, the most commonly used Western drugs combined with Danshen Chuanxiongqin Injection were anticoagulant thrombolytic and antiplatelet drugs, with a usage rate as high as 83.48%. In order to further explore the drug combination rules of Danshen Chuanxiongqin Injection, the association analysis of drug combination in patients of cerebral infarction treated with Danshen Chuanxiongqin Injection was carried out. In clinical combination of two Western drugs, Atorvastatin Calcium Capsules+Cerebral Proteolytic Injection were the most common combination, with a support of 27.10%. In clinical combination with 3 Western drugs, Clopidogrel Bisulfate Tablets+Atorvastatin Calcium Capsules+Cerebral Proteolytic Injection were most commonly used, with a support of 15.90%. The results showed that the patients of cerebral infarction treated with Danshen Chuanxiongqin Injection were mainly elderly males, and often complicated with hypertension, coronary heart disease, diabetes and other basic diseases. The clinical application of Danshen Chuanxiongqin Injection was principally in line with the guidelines. In the treatment of cerebral infarction, it was often combined with Western medicine anticoagulant thrombolysis, antiplatelet drugs, traditional Chinese medicine blood-activating and stasis-dissolving prescription and other drugs with similar pharmacological effects, with an auxiliary therapeutic effect on patients of cerebral infarction complicated with other diseases, and can provide guidance for clinical medication.
本研究分析了丹红川穹嗪注射液治疗脑梗死患者的临床特征及药物配伍规律。收集了中国20家三级甲等医院HIS数据库中2857例使用丹红川穹嗪注射液治疗的脑梗死患者的住院信息，通过描述性分析和Apriori算法建立模型，以探讨丹红川穹嗪注射液治疗脑梗死的临床特征及药物配伍规律。结果显示，在使用丹红川穹嗪注射液治疗的脑梗死患者中，年龄大于65岁者1727例，占69.61%；男性1610例，占63.59%。常用药物包括降脂药、抗凝溶栓药、抗血小板药、脑代谢激活剂、血管扩张剂等西药，以及活血化瘀药、清热药、祛痰药等中药。与丹红川穹嗪注射液联用使用频率最高的西药是阿司匹林肠溶片（1528例，53.48%）。与丹红川穹嗪注射液联用使用频率最高的中药是醒脑静注射液，共378例，占13.23%。其中，与丹红川穹嗪注射液联用最常用的西药是抗凝溶栓药和抗血小板药，使用率高达83.48%。为进一步探究丹红川穹嗪注射液的药物配伍规律，对使用丹红川穹嗪注射液治疗的脑梗死患者进行药物联用关联分析。在两种西药的临床联用中，阿托伐他汀钙片+脑蛋白水解物注射液是最常见的组合，支持度为27.10%。在三种西药联用中，硫酸氢氯吡格雷片+阿托伐他汀钙片+脑蛋白水解物注射液最常用，支持度为15.90%。结果表明，使用丹红川穹嗪注射液治疗的脑梗死患者以老年男性为主，常合并高血压、冠心病、糖尿病等基础疾病。丹红川穹嗪注射液的临床应用基本符合指南。在脑梗死治疗中，常与西药抗凝溶栓、抗血小板药物，中药活血化瘀方剂等药理作用相似的药物联用，对合并其他疾病的脑梗死患者有辅助治疗作用，可为临床用药提供指导。
