估算肾小球滤过率正常的患者中中性粒细胞与淋巴细胞比值和微量白蛋白尿的关联。
Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR.
作者信息
Kutlugun Aysun Aybal, Ebinc Fatma Ayerden, Ozturk Mujgan Tek, Efe Fatma Kaplan, Karadag İbrahim, Eser Murat, Unsal Oktay, Karakaya Serdar
机构信息
Department of Nephrology, Keçioren Education and Research Hospital, Ankara, Turkey.
Department of Cardiology, Keçioren Education and Research Hospital, Ankara, Turkey.
出版信息
Rom J Intern Med. 2018 Mar 1;56(1):21-26. doi: 10.1515/rjim-2017-0036.
AIMS
The aim of this study was to evaluate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and microalbuminuria in patients with normal estimated glomerular filtration rate (eGFR).
METHODS
174 patients who had eGFR ≥ 60 mL/min/1.73 m2 were studied. Patients were divided into two groups according to the urinary albumin excretion as microalbuminuric group (n = 105) and normoalbuminuric group (n = 69). NLR and PLR levels were calculated.
RESULTS
NLR was significantly higher (p < 0.05) in microalbuminuric patients (1.91 ± 0.70) compared with normoalbuminuric patients (1.63 ± 0.53). A positive correlation was found between urine albumin excretion and NLR in the whole study group (r = 0.214, p < 0.005).
CONCLUSIONS
Higher NLR levels were found in microalbuminuric patients with normal eGFR. Also a significant positive correlation was observed between albuminuria and NLR.
目的
本研究旨在评估估算肾小球滤过率（eGFR）正常的患者中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）与微量白蛋白尿之间的关联。
方法
对174例eGFR≥60 mL/min/1.73 m²的患者进行研究。根据尿白蛋白排泄情况将患者分为两组，即微量白蛋白尿组（n = 105）和正常白蛋白尿组（n = 69）。计算NLR和PLR水平。
结果
微量白蛋白尿患者的NLR（1.91±0.70）显著高于正常白蛋白尿患者（1.63±0.53）（p < 0.05）。在整个研究组中，尿白蛋白排泄与NLR之间存在正相关（r = 0.214，p < 0.005）。
结论
eGFR正常的微量白蛋白尿患者中NLR水平较高。此外，蛋白尿与NLR之间存在显著正相关。
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