Nigde Omer Halisdemir University Training and Research Hospital, Clinical Biochemistry Laboratory,Aşağı Kayabaşı Mah. Hastaneler Cad., Kumluca Mevki, 51100 Merkez/Nigde, Turkey.
Nigde Omer Halisdemir University Training and Research Hospital, Clinical Biochemistry Laboratory,Aşağı Kayabaşı Mah. Hastaneler Cad., Kumluca Mevki, 51100 Merkez/Nigde, Turkey.
J Diabetes Complications. 2024 Sep;38(9):108807. doi: 10.1016/j.jdiacomp.2024.108807. Epub 2024 Jul 8.
We aimed to examine the role of circulating immature granulocytes (IGs) in assessing Diabetic Nephropathy (DN) mainly and also associations of other leukocyte parameters with DN.
In this retrospective cross-sectional study, a total of 164 Diabetes Mellitus patients were grouped as normoalbuminuric and microalbuminuric according to urinary albumin excretion in the course of admission. Neutrophil-lymphocyte ratio (NLR), IG count (IG#) and IG percentage (IG%) levels were compared between the groups. The value of IG# and IG% levels in detecting microalbuminuria was analyzed with the Receiver operating characteristic (ROC) curve.
NLR was remarkably higher in the microalbuminuric group (p = 0.036). Correlation results in the microalbuminuric group were as follows: A feeble positive correlation between neutrophil count (NEU#) and serum creatinine and albumin-to- creatinine ratio (ACR) (p = 0.036, r = 0.261; p = 0.005, r = 0.347, respectively), a feeble positive correlation between lymphocyte count (LYM#) and estimated glomerular filtration rate (p = 0.021, r = 0.285). Correlation results in the normooalbuminuric group were as follows: A feeble positive correlation between NEU# and ACR (p = 0.043, r = 0.204), a feeble negative correlation between LYM# and serum creatinine (p = 0.042, r = -0.205), a poor positive correlation between IG# and ACR and HBA1C% (p = 0.048, r = 0.199; p = 0.004, r = 0.290, respectively), a positive poor correlation between IG% and HBA1C% (p = 0.019, r = 0.235). Area under the ROC curve values for IG# and IG% were not statistically noteworthy in detecting microalbuminuria (p = 0.430; p = 0.510, respectively).
IG# and IG% values are insufficient to predict immediate microalbuminuria, but could be considered a weak biomarker for renal damage in normoalbuminuric (<30 mg/g) diabetic patients. Further researches are needed for the use of leukocyte parameters in evaluating DN.
本研究旨在探讨循环幼稚粒细胞（IG）在评估糖尿病肾病（DN）中的作用，以及其他白细胞参数与 DN 的相关性。
在这项回顾性的横断面研究中，根据入院期间尿白蛋白排泄情况，将 164 名糖尿病患者分为正常白蛋白尿组和微量白蛋白尿组。比较两组间中性粒细胞与淋巴细胞比值（NLR）、IG 计数（IG#）和 IG 百分比（IG%）水平。用受试者工作特征（ROC）曲线分析 IG#和 IG%水平对微量白蛋白尿的检测价值。
微量白蛋白尿组 NLR 显著升高（p=0.036）。微量白蛋白尿组的相关结果如下：中性粒细胞计数（NEU#）与血清肌酐和白蛋白与肌酐比值（ACR）呈弱正相关（p=0.036，r=0.261；p=0.005，r=0.347），淋巴细胞计数（LYM#）与估计肾小球滤过率（eGFR）呈弱正相关（p=0.021，r=0.285）。正常白蛋白尿组的相关结果如下：NEU#与 ACR 呈弱正相关（p=0.043，r=0.204），LYM#与血清肌酐呈弱负相关（p=0.042，r=-0.205），IG#与 ACR 和糖化血红蛋白（HbA1C）%呈弱正相关（p=0.048，r=0.199；p=0.004，r=0.290），IG%与 HbA1C%呈正相关（p=0.019，r=0.235）。IG#和 IG%的 ROC 曲线下面积值在检测微量白蛋白尿方面无统计学意义（p=0.430；p=0.510）。
IG#和 IG%值不足以预测即时微量白蛋白尿，但可作为正常白蛋白尿（<30mg/g）糖尿病患者肾损伤的弱生物标志物。需要进一步研究白细胞参数在评估 DN 中的应用。
