Zhang Jing-Ya, Ge Peng, Zhang Peng-Yu, Zhao Meng, Ren Li
Clin Lab. 2019 May 1;65(5). doi: 10.7754/Clin.Lab.2018.181040.
Accumulating evidence has revealed that inflammation might play an important role in the genesis and development of cancer. High levels of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ration (PLR) are parameters of systemic inflammation which have been identified to be associated with poor prognosis in PCa. Bone is one of the most common sites of metastasis from prostate cancer; however, there are few studies concerning the correlation of NLR, PLR, and bone metastases in PCa. The aim of this study was to evaluate the performance of neutrophil to lymphocyte ratio (NLR) or platelet to lymphocyte (PLR) in diagnosis of bone metastasis of prostate cancer (PCa).
Data of 74 PCa patients without metastases, 51 PCa patients with bone metastases, and 43 patients with benign prostatic hypertrophy (BPH) were retrospectively reviewed. The difference of patients' clinical and laboratory characteristics of the three groups was comparatively studied. ROC analysis was used to evaluate the benefit of adding NLR or PLR to prostate specific antigen (PSA) in prediction of bone metastases. Depending on this cutoff value, patients were divided into high-NLR or low-NLR group, high-PLR or low-PLR group.
There were significant differences in NLR and PLR between groups with bone metastases and without bone metastases (p = 0.044; p = 0.030), while there was no significant difference between NLR and PLR of the patients with localized prostate cancer and BPH (p = 0.462; p = 0.102). NLR and PLR were correlated with PSA level in the patients with prostate cancer (p = 0.006, r = 0.247; p = 0.025, r = 0.200). The distribution of PSA showed significant differences between the high-NLR and low-NLR group, as well as between the high-PLR and low-PLR group. By applying the ROC curve method, the AUC values of PSA with NLR or PLR were 0.725 and 0.838 (0.763 - 0.913), respectively. Although PSA + PLR had the largest area, there was no statistical significance between PSA + PLR and PSA (p = 0.6992).
NLR and PLR significantly increase in PCa patients with bone metastases and are valuable in the diagnosis of bone metastases in PCa patients.
越来越多的证据表明，炎症可能在癌症的发生和发展中起重要作用。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）升高是全身炎症的指标，已被确定与前列腺癌（PCa）的不良预后相关。骨是前列腺癌最常见的转移部位之一；然而，关于PCa中NLR、PLR与骨转移之间相关性的研究较少。本研究的目的是评估中性粒细胞与淋巴细胞比值（NLR）或血小板与淋巴细胞比值（PLR）在前列腺癌（PCa）骨转移诊断中的作用。
回顾性分析74例无转移的PCa患者、51例有骨转移的PCa患者和43例良性前列腺增生（BPH）患者的数据。比较研究三组患者的临床和实验室特征差异。采用ROC分析评估在前列腺特异性抗原（PSA）基础上增加NLR或PLR对预测骨转移的益处。根据该临界值，将患者分为高NLR或低NLR组、高PLR或低PLR组。
有骨转移组和无骨转移组之间的NLR和PLR存在显著差异（p = 0.044；p = 0.030），而局限性前列腺癌患者和BPH患者的NLR和PLR之间无显著差异（p = 0.462；p = 0.102）。前列腺癌患者的NLR和PLR与PSA水平相关（p = 0.006，r = 0.247；p = 0.025，r = 0.200）。高NLR组与低NLR组之间以及高PLR组与低PLR组之间的PSA分布存在显著差异。应用ROC曲线法，PSA联合NLR或PLR的AUC值分别为0.725和0.838（0.763 - 0.913）。虽然PSA + PLR的面积最大，但PSA + PLR与PSA之间无统计学意义（p = 0.6992）。
有骨转移的PCa患者的NLR和PLR显著升高，对PCa患者骨转移的诊断有价值。
