Valdovinos H F, Hernandez R, Graves S, Ellison P A, Barnhart T E, Theuer C P, Engle J W, Cai W, Nickles R J
Medical Physics Department, University of Wisconsin-Madison, Madison, WI, USA.
Department of Radiology, University of Wisconsin, Madison, WI, USA.
Appl Radiat Isot. 2017 Dec;130:90-101. doi: 10.1016/j.apradiso.2017.09.005. Epub 2017 Sep 6.
This work presents the production with a cyclotron of the positron emitter Co via the Fe(d,n) and Ni(p,α) reactions and the Auger electron emitter Co via the Fe(d,n) reaction after high current (40μA p and 60μA d) irradiation on electroplated targets. High specific activity radionuclides (up to 55.6 GBq/μmol Co and 31.8GBq/μmol Co) with high radionuclidic purity (99.995% Co from Fe, 98.8% Co from Ni, and 98.7% Co from Fe at end of bombardment, EoB), in high activity concentration (final separated radionuclide in < 0.6mL) and with almost quantitative overall activity separation yield (> 92%) were obtained after processing of the irradiated targets with novel radiochemical separation methods based on HCl dissolution and the resin N,N,N',N'-tetrakis-2-ethylhexyldiglycolamide (DGA, branched). One hour long irradiations using 38-65, 110-214 and 59-78mg of enriched Fe (99.93%), Ni (99.48%) and Fe (95.06%), respectively, electroplated over a 1.0cm surface, yielded 58 ± 66MBq Co, 372 ± 14MBq Co and 810 ± 186MBq Co, respectively, decay corrected to EoB. The separation methods allow for the recovery of the costly enriched target materials, which were reconstituted into metallic targets after novel electroplating methods, with an overall recycling efficiency of 93 ± 4% for iron. The produced radionuclides were used to radiolabel the angiogenesis marker antibody TRC105 conjugated to the chelator NOTA as a demonstration of their quality.
这项工作展示了在电镀靶材上进行高电流（40μA质子和60μA氘核）辐照后，通过Fe(d,n)和Ni(p,α)反应利用回旋加速器生产正电子发射体钴，以及通过Fe(d,n)反应生产俄歇电子发射体钴。在基于HCl溶解和树脂N,N,N',N'-四-2-乙基己基二甘醇酰胺（支链DGA）的新型放射化学分离方法处理辐照后的靶材后，获得了高比活度放射性核素（最高可达55.6GBq/μmol钴和31.8GBq/μmol钴），具有高放射性核素纯度（轰击结束时，来自铁的钴为99.995%，来自镍的钴为98.8%，来自铁的钴为98.7%），高活度浓度（最终分离的放射性核素在<0.6mL中），且几乎具有定量的总活度分离产率（>92%）。分别使用38 - 65mg、110 - 214mg和59 - 78mg富集铁（99.93%）、镍（99.48%）和铁（95.06%）电镀在1.0cm表面上进行1小时的辐照，分别产生了58±66MBq钴、372±14MBq钴和810±186MBq钴，衰变校正至轰击结束。这些分离方法能够回收昂贵的富集靶材，在采用新型电镀方法后将其重新制成金属靶材，铁的总体回收效率为93±4%。所生产的放射性核素用于对与螯合剂NOTA偶联的血管生成标记抗体TRC105进行放射性标记，以证明其质量。
