苯环己哌啶抑制蝗虫神经肌肉突触处的递质释放。

Phencyclidine depresses transmitter release at the neuromuscular synapse of the locust.

作者信息

Kornhuber M E, Walther C, Kornhuber J

机构信息

Department of Neurology, University of Ulm, F.R.G.

出版信息

Neurosci Lett. 1987 Dec 16;83(1-2):185-9. doi: 10.1016/0304-3940(87)90238-2.

DOI:10.1016/0304-3940(87)90238-2

PMID:2894623

Abstract

The presynaptic effects of phencyclidine (PCP) were studied in the locust extensor tibiae muscle. The neurally evoked transmitter release is diminished in the presence of 5 x 10(-6) to 5 x 10(-5) M PCP. This is indicated (1) by an increased coefficient of variation of the excitatory junction potentials; (2) by an increased rate of failures (a) with nerve stimulation in low [Ca2+]saline and (b) with focal extracellular stimulation in normal [Ca2+]saline. The rate of spontaneous transmitter release is not affected.

摘要

在蝗虫胫节伸肌中研究了苯环己哌啶（PCP）的突触前效应。在5×10⁻⁶至5×10⁻⁵ M PCP存在的情况下，神经诱发的递质释放减少。这通过以下方面得以表明：（1）兴奋性突触后电位的变异系数增加；（2）失败率增加，（a）在低[Ca²⁺]盐溶液中进行神经刺激时，以及（b）在正常[Ca²⁺]盐溶液中进行局部细胞外刺激时。自发递质释放的速率不受影响。