Department of Clinical Pharmacy, University of California, San Francisco, CA, USA.
J Alzheimers Dis. 2017;60(4):1223-1229. doi: 10.3233/JAD-170549.
The decreased availability of metabolizable energy resources in the central nervous system is hypothesized to be a key factor in the pathogenesis of Alzheimer's disease. More specifically, the age-related decline in the ability of glucose to cross the blood-brain barrier creates a metabolic stress that shifts the normal, benign processing of amyloid-β protein precursor toward pathways associated with the production of amyloid-β plaques and tau-containing neurofibrillary tangles that are characteristic of the disease. The neuroenergetic hypothesis provides insight into the etiology of Alzheimer's disease and illuminates new approaches for diagnosis, monitoring, and treatment.
中枢神经系统中可代谢能量资源的减少被认为是阿尔茨海默病发病机制的一个关键因素。更具体地说，与年龄相关的葡萄糖穿过血脑屏障的能力下降会导致代谢应激，从而使正常的、良性的淀粉样蛋白β前体蛋白的处理途径发生改变，向与淀粉样斑块和含有 tau 的神经原纤维缠结的产生相关的途径转移，这些都是该疾病的特征。神经能量假说为阿尔茨海默病的病因提供了深入的了解，并为诊断、监测和治疗提供了新的方法。
