Barberis Claude, Moorcroft Neil, Arendt Chris, Levit Mikhail, Moreno-Mazza Sandra, Batchelor Joseph, Mechin Ingrid, Majid Tahir
IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham MA 02451, USA.
IDD Medicinal Chemistry, Sanofi Genzyme, 153 Second Avenue, Waltham MA 02451, USA.
Bioorg Med Chem Lett. 2017 Oct 15;27(20):4730-4734. doi: 10.1016/j.bmcl.2017.08.069. Epub 2017 Sep 18.
Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.
新型N-取代氮杂吲哚已被发现可作为PIM1抑制剂。在活性确认初始阶段，X射线晶体结构对化学研究工作起到了重要的导向作用。本文展示了通过X射线晶体学所证实的1和2的非常规结合模式，这是选择和推进先导化合物系列的一个重要因素。
