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钝性创伤性主动脉损伤非手术治疗的决定因素和结果。

Determinants and outcomes of nonoperative management for blunt traumatic aortic injuries.

机构信息

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Tex.

Department of Cardiothoracic and Vascular Surgery, McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth), Houston, Tex; Memorial Hermann Heart & Vascular Institute-Texas Medical Center, Houston, Tex.

出版信息

J Vasc Surg. 2018 Feb;67(2):389-398. doi: 10.1016/j.jvs.2017.07.111. Epub 2017 Sep 22.

Abstract

OBJECTIVE

The natural history and parameters for successful nonoperative management of blunt traumatic aortic injuries (BTAIs) involving the descending aorta are poorly understood. We examined our experience with nonoperative BTAI treatment (anti-impulse, blood pressure) and evaluated for determinants of successful outcomes.

METHODS

We performed a review of our institutional prospective trauma registry database for all BTAI patients from 1999 to 2015. Computed tomography angiography was used to classify aortic injuries on the basis of severity: grade I, intimal tear; grade II, intramural hematoma; grade III, aortic pseudoaneurysm; and grade IV, free rupture. Grade IV injuries were excluded from nonoperative management. Baseline characteristics, clinical outcomes, and follow-up lesion resolution were compared within the medically managed cohort and between surgical and nonoperative groups using univariate and multivariable analysis.

RESULTS

Among 338 BTAI patients admitted between 1999 and 2015, 67 BTAI patients were managed nonoperatively; 26 (54%) had grade I BTAI, 22 (46%) had grade II, and 2 (4%) had grade III. Both grade III injuries required a late thoracic endovascular aortic repair after initial medical management and were excluded from analysis. In all, 48 were managed with initial medical therapy, and the remaining 19 died on admission or before definitive treatment. Among the 48 medically managed, the median age was 34 years, and 14 (29%) were female. Six of the 48 (12%) were transferred from other facilities. There was no significant difference in baseline characteristics or early outcomes between BTAI grades. Median injury resolution time was 39 days for grade I and 62 days for grade II (P = .03). Compared with a surgical cohort, BTAI grade and Abbreviated Injury Scale score for the chest were the only significant determinants of propensity to operate.

CONCLUSIONS

Based on these limited data, it appears that patients with minimal aortic injuries (grades I and II) may be managed medically, with the majority resolving within 8 weeks. Minimal aortic injury is associated with low mortality and excellent intermediate-term outcomes. Further prospective studies are required to validate these findings.

摘要

目的

钝性创伤性主动脉损伤(BTAI)涉及降主动脉的自然病史和成功非手术治疗的参数尚不清楚。我们研究了我们在非手术 BTAI 治疗(抗冲动,血压)方面的经验,并评估了成功结果的决定因素。

方法

我们对 1999 年至 2015 年我们机构前瞻性创伤登记数据库中的所有 BTAI 患者进行了回顾性研究。使用计算机断层血管造影术根据严重程度对主动脉损伤进行分类:I 级,内膜撕裂;II 级,壁内血肿;III 级,主动脉假性动脉瘤;和 IV 级,自由破裂。IV 级损伤被排除在非手术治疗之外。使用单变量和多变量分析比较了医学管理队列内和手术与非手术组之间的基线特征、临床结果和随访病变缓解情况。

结果

在 1999 年至 2015 年间收治的 338 例 BTAI 患者中,67 例 BTAI 患者接受了非手术治疗;26 例(54%)为 I 级 BTAI,22 例(46%)为 II 级,2 例(4%)为 III 级。所有 3 级损伤在初始药物治疗后均需进行晚期胸主动脉腔内修复术,因此均被排除在分析之外。总共 48 例患者接受了初始药物治疗,其余 19 例患者在入院或接受确定性治疗前死亡。在接受医学治疗的 48 例患者中,中位年龄为 34 岁,14 例(29%)为女性。其中 6 例(12%)从其他医疗机构转来。BTAI 分级和早期结果之间的基线特征没有显著差异。I 级的中位损伤缓解时间为 39 天,II 级为 62 天(P =.03)。与手术组相比,BTAI 分级和简明损伤评分(AIS)胸部分值是手术的唯一显著决定因素。

结论

根据这些有限的数据,似乎最小的主动脉损伤(I 级和 II 级)的患者可以接受内科治疗,其中大多数在 8 周内得到缓解。最小的主动脉损伤与低死亡率和极好的中期结果相关。需要进一步的前瞻性研究来验证这些发现。

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