人类4号染色体上11个基因座的成对连锁分析。
Pairwise linkage analysis of 11 loci on human chromosome 4.
作者信息
Murray J C, Buetow K H, Smith M, Carlock L, Chakravarti A, Ferrell R F, Gedamu L, Gilliam C, Shiang R, DeHaven C R
机构信息
Department of Pediatrics, University of Iowa 52242.
出版信息
Am J Hum Genet. 1988 Mar;42(3):490-7.
New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkages are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-( EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.
描述了INP10和白细胞介素2的新限制性片段长度多态性（RFLP）。报告了这两个基因座与4号染色体长臂（4q）上另外九个基因座的55对遗传连锁关系。建立了15个新的连锁关系，并为先前报道的4q上的四个连锁关系添加了新数据。描述了白细胞介素2（T细胞生长因子）、表皮生长因子和乙醇脱氢酶的紧密连锁。观察到男性和女性重组率之间存在显著差异。女性重组率估计是男性重组率的1.27倍。基于这些成对结果，11个基因座的顺序为D4S35 - GC -（ALB/AFP）- MT2P1 - D4S1 - INP10 - ADH3 -（EGF/IL2）-（FBB/FBA/FBG）- MNS。这个初步顺序可作为更详细的多点分析的起点。
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