Division of Child and Adolescent Psychiatry Department of Psychiatry Seoul National University College of Medicine Seoul Republic of Korea.
Department of Public Health Medical Services Seoul National University Bundang Hospital Seong-nam Gyeonggi-do Republic of Korea.
Brain Behav. 2017 Aug 1;7(9):e00785. doi: 10.1002/brb3.785. eCollection 2017 Sep.
The G protein-coupled receptor kinase interacting protein 1 gene () has been proposed to be a risk gene for attention deficit hyperactivity disorder (ADHD), and it regulates the endocytosis of G protein-coupled receptors like dopamine receptors. The purpose of this study was to investigate the interaction effects of and dopamine receptor D4 () gene variants on variables of the continuous performance test (CPT).
This study recruited 255 ADHD patients and 98 healthy controls (HC) who underwent CPT and genetic analyses. The genotypes were classified into two groups (the C/C and C/T genotype groups for 4R homozygotes and others for ) and the genotype × genotype effects were examined using hierarchical multivariable linear regression analyses.
There were significant × effects for commission errors on the CPT in the ADHD group ( = .006). In contrast, there were no significant × effects on any CPT variables in the HC.
The present findings demonstrated that there were significant interaction effects of the and gene variants on impulsivity in ADHD. Replication studies with larger sample sizes that include patients from various ethnic backgrounds are warranted to confirm these findings.
G 蛋白偶联受体激酶相互作用蛋白 1 基因（）被提议为注意缺陷多动障碍（ADHD）的风险基因，它调节多巴胺受体等 G 蛋白偶联受体的内吞作用。本研究旨在探讨和多巴胺受体 D4（）基因变异对连续性能测试（CPT）变量的交互作用影响。
本研究招募了 255 名 ADHD 患者和 98 名健康对照者（HC），他们接受了 CPT 和基因分析。基因型分为两组（4R 纯合子的 C/C 和 C/T 基因型组和其他的），并使用分层多变量线性回归分析检查基因型×基因型效应。
在 ADHD 组中，CPT 的错误率存在显著的×效应（= 0.006）。相比之下，HC 中没有任何 CPT 变量存在显著的×效应。
本研究结果表明，和基因变异对 ADHD 患者的冲动性存在显著的交互作用效应。需要进行更大样本量的复制研究，包括来自不同种族背景的患者，以证实这些发现。
