Department of Neurologythe Second Affiliated Hospital of Shantou University Medical College Shantou Guangdong China.
Department of Preventive Medicine Shantou University Medical College Shantou Guangdong China.
Brain Behav. 2017 Aug 13;7(9):e00792. doi: 10.1002/brb3.792. eCollection 2017 Sep.
The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy (H-MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of H-MRS.
PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent H-MRS. Chemical information was obtained for ratios of N-acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions.
Compared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA/Cr and NAA/Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions (<.01); NAA/Cr and NAA/Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment (<.01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA/Cr ratios in the substantia nigra ( = -.32; =.042).
NAA/Cr and NAA/Cho ratios may be useful metabolic biomarkers for early diagnosis of PD. Multi-voxel H-MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD.
特发性帕金森病（PD）是一种进行性神经退行性疾病，其准确诊断和监测尚未完全实现。本研究旨在通过质子磁共振波谱（H-MRS）确定 PD 大脑和健康对照组的多个区域的神经化学特征。我们旨在跟踪大脑神经化学物质的变化，量化神经元丢失，并进一步确定 H-MRS 的诊断价值。
来自中国南方汕头大学医学院第二附属医院的 PD 患者和健康对照者接受了 H-MRS。对黑质、苍白球、前额叶、海马、楔前叶和背侧丘脑区域的 N-乙酰天冬氨酸与肌酸（NAA/Cr）、N-乙酰天冬氨酸与胆碱（NAA/Cho）和 Cho 与 Cr 的比值进行化学信息采集。
与 20 名健康对照者（12 名男性，年龄 58.75±5.03 岁）相比，42 名患者（21 名男性，年龄 61.60±6.40 岁）的黑质、苍白球、前额叶、海马、楔前叶和背侧丘脑区域的 NAA/Cr 和 NAA/Cho 比值均较低（<.01）；单侧和轻度/无认知障碍的患者的 NAA/Cr 和 NAA/Cho 比值均降低（<.01）；统一帕金森病评定量表评分与黑质 NAA/Cr 比值呈负相关（=-.32；=.042）。
NAA/Cr 和 NAA/Cho 比值可能是 PD 早期诊断的有用代谢生物标志物。多体素 H-MRS 可提供有关大脑神经化学的信息，可能是 PD 神经元丢失诊断和监测的有前途的技术。
