Department of Radiology, Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People's Republic of China.
Brain Imaging Behav. 2014 Mar;8(1):97-101. doi: 10.1007/s11682-013-9251-2.
This study investigates changes in substantia nigra metabolites in Parkinson's disease (PD) using proton magnetic resonance spectroscopy ((1)H- MRS). Thirty patients with asymmetric PD and 20 normal controls were included in this study. Substantia nigra metabolites were detected in all subjects using 3D-multimer (1)H-MRS with a 3.0 T MRI scanner. The relative ratios of NAA/Cr, NAA/Cho, NAA/(Cho + Cr) in the substantia nigra were compared between two sides of asymmetric PD patients as well as between PD patients and controls. Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were observed between PD patients and healthy controls (P < 0.05) as well as between the ipsilateral and contralateral of affected extremity in PD patients (P < 0.05). Significant differences in NAA/Cr, NAA/Cho, NAA/(Cho + Cr) were also observed between patients with mild and severe PD. Thus, we found that (1)H-MRS can be used to detect substantia nigra metabolites in PD patients, which may be useful for early diagnosis and evaluation of PD.
本研究采用质子磁共振波谱（1H-MRS）研究帕金森病（PD）患者黑质代谢物的变化。本研究纳入 30 例不对称性 PD 患者和 20 名正常对照者。所有受试者均使用 3.0T MRI 扫描仪进行 3D 多体（1H-MRS）检测黑质代谢物。比较了不对称性 PD 患者两侧以及 PD 患者与对照组之间黑质 NAA/Cr、NAA/Cho、NAA/（Cho+Cr）的相对比值。PD 患者与健康对照组之间（P<0.05）以及 PD 患者患侧与健侧之间（P<0.05）的 NAA/Cr、NAA/Cho、NAA/（Cho+Cr）均有显著差异。轻中度 PD 患者之间的 NAA/Cr、NAA/Cho、NAA/（Cho+Cr）也有显著差异。因此，我们发现 1H-MRS 可用于检测 PD 患者的黑质代谢物，这可能有助于 PD 的早期诊断和评估。
