用于氰根阴离子检测的纳米生物传感器的构建及其在环境和生物系统中的应用。
Construction of a Nano Biosensor for Cyanide Anion Detection and Its Application in Environmental and Biological Systems.
机构信息
Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macao, China.
出版信息
ACS Sens. 2017 Oct 27;2(10):1517-1522. doi: 10.1021/acssensors.7b00553. Epub 2017 Oct 5.
We have developed a Ag@Au core-shell nanoparticle (NP)/iridium(III) complex-based sensing platform for the sensitive luminescence "turn-on" sensing of cyanide ions, an acutely toxic pollutant. The assay is based on the quenching effect of Ag@Au NPs on the emission of complex 1, but luminescence is restored after the addition of cyanide anions due to their ability to dissolve the Au shell. Our sensing platform exhibited a high sensitivity toward cyanide anions with a detection limit of 0.036 μM, and also showed high selectivity for cyanide over 10-fold excess amounts of other anions. The sensing platform was also successfully applied to monitor cyanide anions in drinking water and in living cells.
我们开发了一种基于 Ag@Au 核壳纳米粒子（NP）/铱（III）配合物的传感平台，用于灵敏的“开启”型对氰离子的荧光传感，氰离子是一种剧毒污染物。该测定法基于 Ag@Au NPs 对配合物 1 的发射的猝灭效应，但加入氰根阴离子后，由于其溶解 Au 壳的能力，荧光恢复。我们的传感平台对氰根阴离子表现出高灵敏度，检测限为 0.036 μM，并且对氰根阴离子的选择性也高于其他阴离子 10 倍以上。该传感平台还成功地应用于饮用水和活细胞中氰根阴离子的监测。
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