De Angelis Claudio, Cortegoso Valdivia Pablo, Venezia Ludovica, Bruno Mauro, Pellicano Rinaldo
Department of Gastroenterology and Digestive Endoscopy, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy -
Department of Gastroenterology and Digestive Endoscopy, AOU Città della Salute e della Scienza, University of Turin, Turin, Italy.
Minerva Endocrinol. 2018 Jun;43(2):212-220. doi: 10.23736/S0391-1977.17.02745-6. Epub 2017 Sep 25.
Zollinger-Ellison syndrome (ZES) is a clinical syndrome characterized by gastric acid hypersecretion due to the ectopic secretion of gastrin by a gastrinoma, a neuroendocrine tumor (NET) which mostly develops in the duodenum and in the pancreas. This syndrome was first described by Zollinger and Ellison in 1964; if left untreated, ZES can lead to multiple complications mainly due to gastric hypersecretion and some patients can suffer from the complications of an advanced metastatic disease. Although its clinical features are considered typical, the diagnosis of ZES is often challenging for the clinician. A previous review was published in 2005 by our group, but in 12 years many things have changed: the diagnostic tools have been improved and many different therapeutical options are now available.
佐林格-埃利森综合征（ZES）是一种临床综合征，其特征是由胃泌素瘤（一种主要发生在十二指肠和胰腺的神经内分泌肿瘤（NET））异位分泌胃泌素导致胃酸分泌过多。该综合征于1964年由佐林格和埃利森首次描述；如果不进行治疗，ZES可导致多种并发症，主要是由于胃酸分泌过多，一些患者可能会出现晚期转移性疾病的并发症。尽管其临床特征被认为是典型的，但ZES的诊断对临床医生来说往往具有挑战性。我们小组曾在2005年发表过一篇综述，但在这12年里很多情况都发生了变化：诊断工具得到了改进，现在有了许多不同的治疗选择。
