Jensen R T, Gardner J D, Raufman J P, Pandol S J, Doppman J L, Collen M J
Ann Intern Med. 1983 Jan;98(1):59-75. doi: 10.7326/0003-4819-98-1-59.
Over the last few years the approach to managing patients with the Zollinger-Ellison syndrome has changed dramatically. The establishment of gastrin hypersecretion by a non-beta islet cell tumor as responsible for the gastric acid hypersecretion, and the subsequent development and widespread availability of gastrin radioimmunoassays have changed the criteria generally used for diagnosis and have led to an increased understanding of syndromes that can mimic Zollinger-Ellison syndrome. With the availability of histamine H2-receptor antagonists, gastric acid hypersecretion can be controlled medically in almost all patients with Zollinger-Ellison syndrome, obviating routine total gastrectomy. With the reduced mortality from gastric acid hypersecretion, increased attention is being focused on the natural history of the gastrinoma. Newer methods of localizing tumors are being investigated with a view to surgical removal of the gastrinoma, and the importance of developing an affective chemotherapeutic regimen is becoming increasingly apparent.
在过去几年中，卓-艾综合征患者的管理方法发生了巨大变化。非β胰岛细胞瘤导致胃泌素分泌过多，进而引起胃酸分泌过多，这一发现以及随后胃泌素放射免疫测定法的发展和广泛应用，改变了通常用于诊断的标准，并使人们对可模仿卓-艾综合征的综合征有了更多了解。随着组胺H2受体拮抗剂的出现，几乎所有卓-艾综合征患者的胃酸分泌过多都可以通过药物控制，从而避免了常规的全胃切除术。由于胃酸分泌过多导致的死亡率降低，人们越来越关注胃泌素瘤的自然病史。正在研究更新的肿瘤定位方法，以期通过手术切除胃泌素瘤，并且制定有效的化疗方案的重要性也日益明显。
