Longnecker S M
Department of Pharmacy, Williamsport Hospital, PA.
Drug Intell Clin Pharm. 1988 Feb;22(2):136-8. doi: 10.1177/106002808802200207.
The symptoms resulting from the hyperinsulinemia of severe refractory metastatic insulinoma were palliated using self-administered divided doses of a long-acting minisomatostatin analog, octreotide. The substance was well tolerated and the attributable side effects were minimal (primarily gastrointestinal complaints). There were significant improvements in peripheral edema, ascites, and serum electrolytes throughout therapy. Serum insulin and glucagon levels were largely unchanged. Computed tomography scans performed during therapy showed stabilization of pancreatic and hepatic disease. Severe, recurrent hypoglycemic episodes due to hyperinsulinemia were reduced both in number and severity for almost a three-month period. This allowed the elimination or reduction of other chronic, supportive medications and improved quality of life.
使用长效微型生长抑素类似物奥曲肽自行分剂量给药，缓解了严重难治性转移性胰岛素瘤高胰岛素血症所导致的症状。该药物耐受性良好，可归因的副作用极小（主要是胃肠道不适）。在整个治疗过程中，外周水肿、腹水和血清电解质均有显著改善。血清胰岛素和胰高血糖素水平基本未变。治疗期间进行的计算机断层扫描显示胰腺和肝脏疾病稳定。几乎在三个月的时间里，由高胰岛素血症引起的严重复发性低血糖发作在数量和严重程度上均有所减少。这使得其他慢性支持性药物得以停用或减量，并改善了生活质量。
