Dewhurst D G
Department of Biological Science, Sheffield City Polytechnic, U.K.
Eur J Pharmacol. 1988 Jan 12;145(2):209-12. doi: 10.1016/0014-2999(88)90232-4.
The effects of several excitatory amino acid receptor antagonists on sensory-evoked electromyographic activity induced by catechol have been studied in urethane-anaesthetised rats. 2-Amino-5-phosphono-valearic acid (1.2 mumol/kg i.c.), cis-2,3-piperidine dicarboxylic acid (1.4 mumol/kg i.c.), gamma-D-glutamyl-glycine (2.0 mumol/kg i.c.), 2-amino-7-phosphono-heptanoic acid (230 mumol/kg i.v.) and MK-801 (5 mg/kg i.p.) all significantly decreased the frequency of occurrence of those components of the sensory evoked EMG dependent on supraspinal structures, but were without effect on the spinal component.
在氨基甲酸乙酯麻醉的大鼠中，研究了几种兴奋性氨基酸受体拮抗剂对儿茶酚诱导的感觉诱发电肌电图活动的影响。2-氨基-5-磷酸戊酸（1.2 μmol/kg，脑室内注射）、顺式-2,3-哌啶二羧酸（1.4 μmol/kg，脑室内注射）、γ-D-谷氨酰甘氨酸（2.0 μmol/kg，脑室内注射）、2-氨基-7-磷酸庚酸（230 μmol/kg，静脉注射）和MK-801（5 mg/kg，腹腔注射）均显著降低了依赖于脊髓上结构的感觉诱发电肌电图这些成分的出现频率，但对脊髓成分无影响。
