兴奋性氨基酸拮抗剂与大鼠海马切片中内源性天冬氨酸和谷氨酸的释放
Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.
作者信息
Connick J H, Stone T W
机构信息
Department of Physiology, St George's Hospital Medical School, London.
出版信息
Br J Pharmacol. 1988 Apr;93(4):863-7. doi: 10.1111/j.1476-5381.1988.tb11473.x.
Abstract
- The effect of excitatory amino acid agonists and antagonists on the efflux of endogenous aspartate and glutamate from the rat hippocampus in vitro was studied. 2. None of the compounds tested had any effect on the basal efflux of endogenous aspartate and glutamate. 3. 2-Amino-5-phosphonovaleric acid (APV), 2-amino-7-phosphonoheptanoic acid (APH) and MK-801 all reduced the potassium-evoked efflux of aspartate and glutamate by between 14.9% and 34.3% (P less than 0.05). 4. The depression of efflux brought about by APV was still observed in the presence of tetrodotoxin. 5. Neither N-methyl-D,L-aspartate nor quinolinic acid had any effect on the potassium-evoked efflux of aspartate and glutamate. 6. These results imply the existence of presynaptic amino acid receptors that are capable of modulating the efflux of endogenous aspartate and glutamate.
摘要
- 研究了兴奋性氨基酸激动剂和拮抗剂对体外大鼠海马体内内源性天冬氨酸和谷氨酸流出的影响。2. 所测试的化合物均对内源性天冬氨酸和谷氨酸的基础流出没有任何影响。3. 2-氨基-5-磷酸戊酸（APV）、2-氨基-7-磷酸庚酸（APH）和MK-801均使钾诱发的天冬氨酸和谷氨酸流出减少了14.9%至34.3%（P小于0.05）。4. 在存在河豚毒素的情况下，仍观察到APV引起的流出抑制。5. N-甲基-D，L-天冬氨酸和喹啉酸对钾诱发的天冬氨酸和谷氨酸流出均无任何影响。6. 这些结果表明存在能够调节内源性天冬氨酸和谷氨酸流出的突触前氨基酸受体。
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