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Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.兴奋性氨基酸拮抗剂与大鼠海马切片中内源性天冬氨酸和谷氨酸的释放
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2
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Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.喹啉酸对大鼠大脑皮层氨基酸体外及体内释放的影响。
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The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.N-甲基-D-天冬氨酸拮抗剂氨基磷酸戊酸和MK-801可减轻大鼠海马切片中齿状颗粒细胞和CA1锥体细胞的缺氧损伤。
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Role of excitatory amino acid receptors in K+- and glutamate-evoked release of endogenous adenosine from rat cortical slices.兴奋性氨基酸受体在钾离子和谷氨酸诱发大鼠皮层切片内源性腺苷释放中的作用
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Evoked release of aspartate and glutamate: disparities between prelabeling and direct measurement.
Brain Res. 1983 Nov 14;278(1-2):279-82. doi: 10.1016/0006-8993(83)90254-8.
3
Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices.
Nature. 1981 Jun 18;291(5816):593-4. doi: 10.1038/291593a0.
4
Quinolinic acid evokes [3H]acetylcholine release in striatal slices: mediation by NMDA-type excitatory amino acid receptors.喹啉酸可诱发纹状体切片中[3H]乙酰胆碱的释放：由NMDA型兴奋性氨基酸受体介导。
Eur J Pharmacol. 1983 Dec 9;96(1-2):111-5. doi: 10.1016/0014-2999(83)90536-8.
5
Presynaptic kainate and N-methyl-D-aspartate receptors regulate excitatory amino acid release in the olfactory cortex.突触前的海人酸受体和N-甲基-D-天冬氨酸受体调节嗅觉皮质中兴奋性氨基酸的释放。
Brain Res. 1983 Apr 11;265(1):157-9. doi: 10.1016/0006-8993(83)91348-3.
6
Differences between the release of radiolabelled and endogenous dopamine from superfused rat brain slices: effects of depolarizing stimuli, amphetamine and synthesis inhibition.从超灌流大鼠脑片中释放的放射性标记多巴胺与内源性多巴胺之间的差异：去极化刺激、苯丙胺及合成抑制的影响
Brain Res. 1985 Dec 2;348(2):309-20. doi: 10.1016/0006-8993(85)90450-0.
7
The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.
Biochem Pharmacol. 1986 Oct 15;35(20):3631-5. doi: 10.1016/0006-2952(86)90636-2.
8
NMDA receptors and ligands in the vertebrate CNS.
Prog Neurobiol. 1988;30(4):333-68. doi: 10.1016/0301-0082(88)90027-5.
9
Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones.镁离子对氨基酸诱导的脊髓神经元去极化的选择性拮抗作用。
Experientia. 1977 Apr 15;33(4):489-91. doi: 10.1007/BF01922227.

兴奋性氨基酸拮抗剂与大鼠海马切片中内源性天冬氨酸和谷氨酸的释放

Excitatory amino acid antagonists and endogenous aspartate and glutamate release from rat hippocampal slices.

作者信息

Connick J H, Stone T W

机构信息

Department of Physiology, St George's Hospital Medical School, London.

出版信息

Br J Pharmacol. 1988 Apr;93(4):863-7. doi: 10.1111/j.1476-5381.1988.tb11473.x.

DOI:10.1111/j.1476-5381.1988.tb11473.x
PMID:2898958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1853891/
Abstract
  1. The effect of excitatory amino acid agonists and antagonists on the efflux of endogenous aspartate and glutamate from the rat hippocampus in vitro was studied. 2. None of the compounds tested had any effect on the basal efflux of endogenous aspartate and glutamate. 3. 2-Amino-5-phosphonovaleric acid (APV), 2-amino-7-phosphonoheptanoic acid (APH) and MK-801 all reduced the potassium-evoked efflux of aspartate and glutamate by between 14.9% and 34.3% (P less than 0.05). 4. The depression of efflux brought about by APV was still observed in the presence of tetrodotoxin. 5. Neither N-methyl-D,L-aspartate nor quinolinic acid had any effect on the potassium-evoked efflux of aspartate and glutamate. 6. These results imply the existence of presynaptic amino acid receptors that are capable of modulating the efflux of endogenous aspartate and glutamate.
摘要
  1. 研究了兴奋性氨基酸激动剂和拮抗剂对体外大鼠海马体内内源性天冬氨酸和谷氨酸流出的影响。2. 所测试的化合物均对内源性天冬氨酸和谷氨酸的基础流出没有任何影响。3. 2-氨基-5-磷酸戊酸（APV）、2-氨基-7-磷酸庚酸（APH）和MK-801均使钾诱发的天冬氨酸和谷氨酸流出减少了14.9%至34.3%（P小于0.05）。4. 在存在河豚毒素的情况下，仍观察到APV引起的流出抑制。5. N-甲基-D，L-天冬氨酸和喹啉酸对钾诱发的天冬氨酸和谷氨酸流出均无任何影响。6. 这些结果表明存在能够调节内源性天冬氨酸和谷氨酸流出的突触前氨基酸受体。