新型海洋生物碱海膜素的α-肾上腺素能受体阻断作用
Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.
作者信息
Kobayashi J, Nakamura H, Ohizumi Y
机构信息
Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.
出版信息
Experientia. 1988 Jan 15;44(1):86-7. doi: 10.1007/BF01960260.
PMID:2895014
Abstract
In the rabbit isolated aorta, hymenin (10(-6) M), a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.
摘要
在兔离体主动脉中，新型海洋生物碱海曼宁（10⁻⁶ M）使去甲肾上腺素的剂量 - 反应曲线平行右移，而不影响组胺或氯化钾的剂量 - 反应曲线，这表明海曼宁是血管平滑肌中α - 肾上腺素能受体的竞争性拮抗剂。
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