• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型海洋生物碱海膜素的α-肾上腺素能受体阻断作用

Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.

作者信息

Kobayashi J, Nakamura H, Ohizumi Y

机构信息

Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.

出版信息

Experientia. 1988 Jan 15;44(1):86-7. doi: 10.1007/BF01960260.

DOI:10.1007/BF01960260
PMID:2895014
Abstract

In the rabbit isolated aorta, hymenin (10(-6) M), a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.

摘要

在兔离体主动脉中，新型海洋生物碱海曼宁（10⁻⁶ M）使去甲肾上腺素的剂量 - 反应曲线平行右移，而不影响组胺或氯化钾的剂量 - 反应曲线，这表明海曼宁是血管平滑肌中α - 肾上腺素能受体的竞争性拮抗剂。

相似文献

1
Alpha-adrenoceptor blocking action of hymenin, a novel marine alkaloid.新型海洋生物碱海膜素的α-肾上腺素能受体阻断作用
Experientia. 1988 Jan 15;44(1):86-7. doi: 10.1007/BF01960260.
2
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.
J Pharm Pharmacol. 1984 Nov;36(11):785-6. doi: 10.1111/j.2042-7158.1984.tb04876.x.
3
Hymenin, a novel alpha-adrenoreceptor blocking agent from the Okinawan marine sponge Hymeniacidon sp.膜海鞘素，一种从冲绳海洋海绵膜海鞘属物种中提取的新型α-肾上腺素能受体阻断剂。
Experientia. 1986 Sep 15;42(9):1064-5. doi: 10.1007/BF01940735.
4
Postjunctional alpha-adrenoceptors in the rabbit isolated distal saphenous artery: indirect sensitivity to prazosin of responses to noradrenaline mediated via postjunctional alpha 2-adrenoceptors.兔离体隐静脉远段的节后α-肾上腺素能受体：通过节后α2-肾上腺素能受体介导的对去甲肾上腺素反应对哌唑嗪的间接敏感性。
Br J Pharmacol. 1991 Jun;103(2):1484-92. doi: 10.1111/j.1476-5381.1991.tb09815.x.
5
Investigation of the subtypes of alpha 1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen.介导大鼠主动脉、输精管和脾脏收缩的α1-肾上腺素能受体亚型的研究。
Br J Pharmacol. 1993 May;109(1):80-7. doi: 10.1111/j.1476-5381.1993.tb13534.x.
6
Two pharmacologically distinct alpha 1-adrenoceptor subtypes in the contraction of rabbit aorta: each subtype couples with a different Ca2+ signalling mechanism and plays a different physiological role.兔主动脉收缩中两种药理学特性不同的α1-肾上腺素能受体亚型：每种亚型与不同的Ca2+信号传导机制偶联并发挥不同的生理作用。
Mol Pharmacol. 1990 Nov;38(5):725-36.
7
Perezone relaxing vascular action.崖柏酮具有舒张血管的作用。
Proc West Pharmacol Soc. 1992;35:93-6.
8
Alpha 2-adrenoceptor blocking profile of SK&F 104078: further evidence for receptor subtypes.SK&F 104078的α2-肾上腺素能受体阻断特性：受体亚型的进一步证据。
Br J Pharmacol. 1991 Apr;102(4):943-9. doi: 10.1111/j.1476-5381.1991.tb12281.x.
9
Nifedipine and alpha adrenoceptors in rat aorta. II. Role of extracellular calcium in enhanced alpha-2 adrenoceptor-mediated contraction in diabetes.硝苯地平与大鼠主动脉中的α肾上腺素能受体。II. 细胞外钙在糖尿病中增强的α-2肾上腺素能受体介导的收缩中的作用。
J Pharmacol Exp Ther. 1984 Dec;231(3):603-9.
10
[Effect of (-)-stepholidine on blood pressure and alpha-adrenoceptor agonists-, KCl- and CaCl2-evoked contractions of aortic strips].（-）-千金藤啶碱对血压及α-肾上腺素受体激动剂、氯化钾和氯化钙引起的主动脉条收缩的影响
Zhongguo Yao Li Xue Bao. 1991 Nov;12(6):514-8.

引用本文的文献

1
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds.通过2-氨基-4-芳基咪唑与羰基和亚甲基活性化合物的多米诺反应合成新型（2-氨基-4-芳基咪唑基）丙酸和吡咯并[1,2-]咪唑。
Beilstein J Org Chem. 2019 May 6;15:1032-1045. doi: 10.3762/bjoc.15.101. eCollection 2019.
2
Recent progress in neuroactive marine natural products.海洋天然产物的神经活性研究进展。
Nat Prod Rep. 2014 Jan 17;31(2):273-309. doi: 10.1039/c3np70083f.
3
Symbioramide, a novel Ca2+-ATPase activator from the cultured dinoflagellate Symbiodinium sp.

本文引用的文献

1
Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.累积剂量-反应曲线。II. 离体器官中剂量-反应曲线的制作技术及药物参数的评估
Arch Int Pharmacodyn Ther. 1963;143:299-330.
2
Ca2+ channel activating function of maitotoxin, the most potent marine toxin known, in clonal rat pheochromocytoma cells.已知最强效的海洋毒素——刺尾鱼毒素在克隆大鼠嗜铬细胞瘤细胞中的钙离子通道激活功能。
J Biol Chem. 1983 Sep 25;258(18):10944-9.
3
Contractile response of the rabbit aorta to maitotoxin, the most potent marine toxin.
共生酰胺，一种从培养的甲藻共生藻属中提取的新型钙离子ATP酶激活剂
Experientia. 1988 Sep 15;44(9):800-2. doi: 10.1007/BF01959173.
4
Anti-muscarinic activity of a family of C11N5 compounds isolated from Agelas sponges.从艾氏海绵中分离出的一类C11N5化合物的抗毒蕈碱活性。
Experientia. 1992 Sep 15;48(9):885-7. doi: 10.1007/BF02118426.
兔主动脉对最强大的海洋毒素—— maitotoxin的收缩反应。
J Physiol. 1983 Apr;337:711-21. doi: 10.1113/jphysiol.1983.sp014650.
4
Hypotensive effects of N,N-din-n-propylodopamine in the anesthetized dog: comparison with sodium nitroprusside.
J Cardiovasc Pharmacol. 1980;2(3):247-55. doi: 10.1097/00005344-198005000-00003.
5
Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle.
J Pharm Pharmacol. 1984 Nov;36(11):785-6. doi: 10.1111/j.2042-7158.1984.tb04876.x.
6
Chemicals as tools in the study of excitable membranes.化学物质作为研究可兴奋膜的工具。
Physiol Rev. 1974 Oct;54(4):813-89. doi: 10.1152/physrev.1974.54.4.813.
7
A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp.
Experientia. 1986 Oct 15;42(10):1176-7. doi: 10.1007/BF01941300.
8
Hymenin, a novel alpha-adrenoreceptor blocking agent from the Okinawan marine sponge Hymeniacidon sp.膜海鞘素，一种从冲绳海洋海绵膜海鞘属物种中提取的新型α-肾上腺素能受体阻断剂。
Experientia. 1986 Sep 15;42(9):1064-5. doi: 10.1007/BF01940735.
9
Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker.由多肽通道阻滞剂石房蛤毒素 II 对 [3H] 石房蛤毒素与骨骼肌钠通道结合的特异性抑制作用。
J Biol Chem. 1986 May 15;261(14):6149-52.
10
Bromo-eudistomin D, a novel inducer of calcium release from fragmented sarcoplasmic reticulum that causes contractions of skinned muscle fibers.
J Biol Chem. 1986 Mar 25;261(9):4139-42.