Jackson Heart Study, School of Public Health, Jackson State University, Jackson, MS, USA.
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Atherosclerosis. 2017 Nov;266:41-47. doi: 10.1016/j.atherosclerosis.2017.09.016. Epub 2017 Sep 15.
In European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs).
Analyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples.
Adjusting for established CVD risk factors, longer LTL was significantly associated with lower prevalence of coronary artery calcification (CAC) (odds ratio (OR) = 0.810) per 1 kb increase in LTL; (95% confidence interval [CI] 0.656, 0.9998), p=0.0498). Longer LTL was also associated with higher ankle brachial index (ABI) (β = 0.023; (95% CI 0.004, 0.042), p=0.017) when comparing the highest to the lowest LTL quartile. There were no significant associations between LTL and abdominal aortic calcification, carotid intima-media thickness, or left ventricular mass. After a median follow-up of 9 years, longer LTL was associated with lower risk of incident ischemic stroke (hazard ratio (HR) 0.69 (95% CI 0.48, 0.99), p=0.044) and total mortality (HR 0.81 (95% CI 0.67, 0.97), p=0.026) in age and sex adjusted models, but these associations were no longer significant in fully adjusted models.
Among a community-based cohort of AAs, longer LTL was nominally associated with lower odds of CAC and increased ABI, indicative of decreased prevalence of subclinical atherosclerosis and peripheral arterial disease. These findings do not offer strong support for LTL as an independent biomarker of CVD risk in AAs.
在欧洲血统人群中，白细胞端粒长度（LTL）较短与亚临床动脉粥样硬化、心血管疾病（CVD）和死亡率相关，而 LTL 较长与左心室肥厚程度增加相关。我们评估了 LTL 与非裔美国人（AA）亚临床心血管疾病指标和临床事件及死亡率的关系。
分析仅限于基线血样中通过Southern blot 测量 LTL 的 2518 名 JHS 参与者。
在校正了已确立的 CVD 风险因素后，LTL 每增加 1kb，冠状动脉钙化（CAC）的患病率显著降低（比值比（OR）=0.810；95%置信区间（CI）0.656，0.9998）；p=0.0498）。LTL 较长也与较高的踝臂指数（ABI）相关（β=0.023；95%CI 0.004，0.042）；p=0.017）。LTL 与腹主动脉钙化、颈动脉内膜中层厚度或左心室质量之间没有显著相关性。中位随访 9 年后，LTL 较长与缺血性卒中（危险比（HR）0.69（95%CI 0.48，0.99），p=0.044）和全因死亡率（HR 0.81（95%CI 0.67，0.97），p=0.026）的风险降低相关，在校正年龄和性别后的模型中，但在完全校正模型中这些相关性不再显著。
在一个基于社区的 AA 队列中，LTL 较长与 CAC 的几率降低和 ABI 增加相关，表明亚临床动脉粥样硬化和外周动脉疾病的患病率降低。这些发现并不能为 LTL 作为 AA 心血管疾病风险的独立生物标志物提供有力支持。
