Jiang C S, Gibson J B, Wilks A V, Freeth A L
Population Genetics Group, Research School of Biological Sciences, Australian National University, Canberra City, A.C.T.
Heredity (Edinb). 1988 Feb;60 ( Pt 1):101-7. doi: 10.1038/hdy.1988.15.
The restriction endonuclease variation in the 12 kb region surrounding twelve Adh null alleles extracted from three Tasmanian populations has been compared with normal alleles from the same populations. Each of the null alleles had the same haplotype as revealed by digestions with eight hexanucleotide restriction enzymes. This haplotype also occurred in 4 of the 46 chromosomes bearing normal alleles which were tested; these four chromosomes with the null allele haplotype carried the AdhS allele. The data suggest that the Adh null alleles from geographically separate populations share a common ancestry and are derived from the same mutation in an AdhS allele.
从塔斯马尼亚三个种群中提取的12个乙醇脱氢酶（Adh）无效等位基因周围12kb区域内的限制性内切酶变异，已与同一种群中的正常等位基因进行了比较。通过用8种六核苷酸限制性内切酶消化发现，每个无效等位基因都具有相同的单倍型。在检测的46条携带正常等位基因的染色体中，有4条也出现了这种单倍型；这4条具有无效等位基因单倍型的染色体携带AdhS等位基因。数据表明，来自地理上分离种群的Adh无效等位基因有着共同的祖先，且源自AdhS等位基因中的同一突变。
