Veuille M, Bénassi V, Aulard S, Depaulis F
Laboratoire d'Ecologie, Ecole Pratique des Hautes Etudes, Unité de Recherche Associée 258, Université Paris-6, 75005 Paris, France.
Genetics. 1998 Jun;149(2):971-81. doi: 10.1093/genetics/149.2.971.
The history of the Drosophila melanogaster alcohol dehydrogenase (ADH) Fast/Slow polymorphism was studied by recording molecular variation and inversion polymorphism in 233 chromosomes from European and African populations. Silent molecular variation in the Slow allele was very different between standard chromosomes and chromosomes bearing the In(2L)t inversion. Within populations, inverted Slow haplotypes were more variable than standard Slow haplotypes. Between populations, geographical structure was almost nonexistent for inverted Slow haplotypes and highly significant for standard Slow. All Fast haplotypes occurred on standard chromosomes. They showed little variation within and between populations. They were highly significantly closer to standard Slow haplotypes from Europe. These results suggest that the current range of Fast and In(2L)t Slow haplotypes is recent and that an older genetic differentiation between populations was followed by allele-specific gene flow.
通过记录来自欧洲和非洲种群的233条染色体中的分子变异和倒位多态性，对黑腹果蝇乙醇脱氢酶（ADH）快/慢多态性的历史进行了研究。标准染色体与携带In(2L)t倒位的染色体之间，慢等位基因中的沉默分子变异存在很大差异。在种群内部，倒位的慢单倍型比标准慢单倍型更具变异性。在种群之间，倒位慢单倍型几乎不存在地理结构，而标准慢单倍型的地理结构则非常显著。所有快单倍型都出现在标准染色体上。它们在种群内部和种群之间几乎没有变异。它们与来自欧洲的标准慢单倍型高度显著地更为接近。这些结果表明，当前快单倍型和In(2L)t慢单倍型的分布范围是最近形成的，并且种群之间较早的遗传分化之后是等位基因特异性的基因流动。
