• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇大肠中Delta-Notch依赖性边界形成的建模与分析

Modeling and analysis of the Delta-Notch dependent boundary formation in the Drosophila large intestine.

作者信息

Liu Fei, Sun Deshun, Murakami Ryutaro, Matsuno Hiroshi

机构信息

Control and Simulation Center, Harbin Institute of Technology, West Dazhi Street 92, Harbin, 150001, People's Republic of China.

School of Software Engineering, South China University of Technology, Building B7, Guangzhou, 510006, People's Republic of China.

出版信息

BMC Syst Biol. 2017 Sep 21;11(Suppl 4):80. doi: 10.1186/s12918-017-0455-8.

DOI:10.1186/s12918-017-0455-8
PMID:28950873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5615251/
Abstract

BACKGROUND

The boundary formation in the Drosophila large intestine is widely studied as an important biological problem. It has been shown that the Delta-Notch signaling pathway plays an essential role in the formation of boundary cells.

RESULTS

In this paper, we propose a mathematical model for the Delta-Notch dependent boundary formation in the Drosophila large intestine in order to better interpret related experimental findings of this biological phenomenon. To achieve this, we not only perform stability analysis on the model from a theoretical point of view, but also perform numerical simulations to analyze the model with and without noises, the phenotype change with the change of Delta or Notch expression, and the perturbation influences of binding and inhibition parameters on the boundary formation.

CONCLUSIONS

By doing all these work, we can assure that our model can better interpret the biological findings related to the boundary formation in the Drosophila large intestine.

摘要

背景

果蝇大肠中的边界形成作为一个重要的生物学问题受到广泛研究。已表明Delta-Notch信号通路在边界细胞的形成中起着至关重要的作用。

结果

在本文中，我们提出了一个关于果蝇大肠中Delta-Notch依赖性边界形成的数学模型，以便更好地解释这一生物学现象的相关实验结果。为实现这一目标，我们不仅从理论角度对模型进行稳定性分析，还进行数值模拟，以分析有噪声和无噪声情况下的模型、Delta或Notch表达变化时的表型变化，以及结合和抑制参数对边界形成的扰动影响。

结论

通过开展所有这些工作，我们可以确保我们的模型能够更好地解释与果蝇大肠中边界形成相关的生物学发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/1e7df2ae85ba/12918_2017_455_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/436931aea15c/12918_2017_455_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/16c3c8a42ee3/12918_2017_455_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/51742e768972/12918_2017_455_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/ef60e04ef110/12918_2017_455_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/96f76d8fda22/12918_2017_455_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/a69c25890414/12918_2017_455_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/3b1f8fece693/12918_2017_455_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/92c967395003/12918_2017_455_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/9e69484f203e/12918_2017_455_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/24c521c337b6/12918_2017_455_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/189f4d9b8b1b/12918_2017_455_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/3c413f224128/12918_2017_455_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/1e7df2ae85ba/12918_2017_455_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/436931aea15c/12918_2017_455_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/16c3c8a42ee3/12918_2017_455_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/51742e768972/12918_2017_455_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/ef60e04ef110/12918_2017_455_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/96f76d8fda22/12918_2017_455_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/a69c25890414/12918_2017_455_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/3b1f8fece693/12918_2017_455_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/92c967395003/12918_2017_455_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/9e69484f203e/12918_2017_455_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/24c521c337b6/12918_2017_455_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/189f4d9b8b1b/12918_2017_455_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/3c413f224128/12918_2017_455_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bdb/5615251/1e7df2ae85ba/12918_2017_455_Fig13_HTML.jpg

相似文献

1
Modeling and analysis of the Delta-Notch dependent boundary formation in the Drosophila large intestine.果蝇大肠中Delta-Notch依赖性边界形成的建模与分析
BMC Syst Biol. 2017 Sep 21;11(Suppl 4):80. doi: 10.1186/s12918-017-0455-8.
2
Boundary formation by notch signaling in Drosophila multicellular systems: experimental observations and gene network modeling by Genomic Object Net.果蝇多细胞系统中Notch信号介导的边界形成：实验观察与基因组对象网络的基因网络建模
Pac Symp Biocomput. 2003:152-63.
3
The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs.蜕皮激素和Notch信号通路协同调控果蝇翅芽背腹边界处的Cut蛋白。
J Genet Genomics. 2016 Apr 20;43(4):179-86. doi: 10.1016/j.jgg.2016.03.002. Epub 2016 Mar 17.
4
Monitoring notch/delta endosomal trafficking and signaling in Drosophila.监测果蝇中Notch/Delta内体运输与信号传导
Methods Enzymol. 2014;534:301-21. doi: 10.1016/B978-0-12-397926-1.00017-2.
5
Mathematical study of the role of Delta/Notch lateral inhibition during primary branching of Drosophila trachea development.数学研究 Delta/Notch 侧向抑制在果蝇气管发育初级分支过程中的作用。
Biophys J. 2012 Dec 19;103(12):2549-59. doi: 10.1016/j.bpj.2012.11.005. Epub 2012 Dec 18.
6
A Delta-Notch signaling border regulated by Engrailed/Invected repression specifies boundary cells in the Drosophila hindgut.由Engrailed/Invected抑制调控的Delta-Notch信号边界决定了果蝇后肠中的边界细胞。
Mech Dev. 2002 Jun;114(1-2):71-84. doi: 10.1016/s0925-4773(02)00061-8.
7
Notch signaling controls cell fate specification along the dorsoventral axis of the Drosophila gut.Notch信号通路控制果蝇肠道背腹轴上的细胞命运特化。
Curr Biol. 2002 Feb 5;12(3):171-9. doi: 10.1016/s0960-9822(02)00653-x.
8
IMP regulates Kuzbanian to control the timing of Notch signalling in follicle cells.IMP 调控 Kuzbanian 以控制滤泡细胞中 Notch 信号的时机。
Development. 2019 Jan 18;146(2):dev168963. doi: 10.1242/dev.168963.
9
Cell-fate choice and boundary formation by combined action of Notch and engrailed in the Drosophila hindgut.Notch与engrailed在果蝇后肠中的联合作用决定细胞命运并形成边界
Dev Genes Evol. 2002 Dec;212(11):534-41. doi: 10.1007/s00427-002-0262-z. Epub 2002 Oct 3.
10
Robust selection of sensory organ precursors by the Notch-Delta pathway.Notch-Delta 通路对感觉器官前体细胞的稳健选择。
Curr Opin Cell Biol. 2011 Dec;23(6):663-7. doi: 10.1016/j.ceb.2011.09.005. Epub 2011 Sep 29.

引用本文的文献

1
Mathematical modeling and application of IL-1β/TNF signaling pathway in regulating chondrocyte apoptosis.白细胞介素-1β/肿瘤坏死因子信号通路调控软骨细胞凋亡的数学建模与应用
Front Cell Dev Biol. 2023 Nov 2;11:1288431. doi: 10.3389/fcell.2023.1288431. eCollection 2023.
2
Analysis of an improved fractional-order model of boundary formation in the large intestine dependent on Delta-Notch pathway.基于Delta-Notch信号通路的大肠边界形成改进分数阶模型分析
Adv Differ Equ. 2020;2020(1):377. doi: 10.1186/s13662-020-02836-1. Epub 2020 Jul 23.

本文引用的文献

1
Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.Notch信号通路中的锯齿状-三角洲不对称性可导致发送者/接收者混合表型。
Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E402-9. doi: 10.1073/pnas.1416287112. Epub 2015 Jan 20.
2
Modelling and simulating reaction-diffusion systems using coloured Petri nets.使用有色Petri网对反应扩散系统进行建模与仿真。
Comput Biol Med. 2014 Oct;53:297-308. doi: 10.1016/j.compbiomed.2014.07.004. Epub 2014 Jul 15.
3
Apical localisation of crumbs in the boundary cells of the Drosophila hindgut is independent of its canonical interaction partner stardust.
果蝇后肠边界细胞中crumbs的顶端定位独立于其典型相互作用伴侣星尘。
PLoS One. 2014 Apr 7;9(4):e94038. doi: 10.1371/journal.pone.0094038. eCollection 2014.
4
A review of techniques for parameter sensitivity analysis of environmental models.环境模型参数敏感性分析技术综述。
Environ Monit Assess. 1994 Sep;32(2):135-54. doi: 10.1007/BF00547132.
5
Modelling biological systems from molecules to dynamical networks.从分子到动态网络的生物系统建模。
BMC Syst Biol. 2012;6 Suppl 1(Suppl 1):S1. doi: 10.1186/1752-0509-6-S1-S1. Epub 2012 Jul 16.
6
Dorsoventral patterning of the Drosophila hindgut is determined by interaction of genes under the control of two independent gene regulatory systems, the dorsal and terminal systems.果蝇后肠的背腹模式由两个独立的基因调控系统——背侧系统和末端系统控制下的基因相互作用决定。
Mech Dev. 2012 Sep-Dec;129(9-12):236-43. doi: 10.1016/j.mod.2012.07.006. Epub 2012 Aug 7.
7
Computational approaches to developmental patterning.计算方法在发育模式中的应用。
Science. 2012 Apr 13;336(6078):187-91. doi: 10.1126/science.1215478.
8
Modelling the Bicoid gradient.建立 Bicoid 梯度模型。
Development. 2010 Jul;137(14):2253-64. doi: 10.1242/dev.032409.
9
Cis-interactions between Notch and Delta generate mutually exclusive signalling states.Notch 和 Delta 之间的顺式相互作用产生相互排斥的信号状态。
Nature. 2010 May 6;465(7294):86-90. doi: 10.1038/nature08959. Epub 2010 Apr 25.
10
Interactions between zebrafish pigment cells responsible for the generation of Turing patterns.斑马鱼色素细胞之间的相互作用，这些色素细胞负责图灵模式的产生。
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8429-34. doi: 10.1073/pnas.0808622106. Epub 2009 May 11.