Ferragut J F, Bentayebi K, Pereira R, Castro J A, Amorim A, Ramon C, Picornell A
Institut Universitari d'Investigació en Ciències de la Salut (IUNICS) i Laboratori de Genètica, Departament de Biologia, Universitat de les Illes Balears, Carretera de Valldemossa, km 7.5, 07122, Palma de Mallorca, Illes Balears, Spain.
Biochemistry and Immunology Laboratory-Forensic Unit, Mohammed V Agdal University, Faculty of Sciences, Avenue Ibn Batouta Agdal, BP 1014 Rabat, Morocco.
Forensic Sci Int Genet. 2017 Nov;31:e5-e11. doi: 10.1016/j.fsigen.2017.09.008. Epub 2017 Sep 18.
Population genetic data for 53 X-chromosome markers (32 X-indels, 9 X-Alu insertions and 12 X-STRs) are reported for five populations with Jewish ancestry (Sephardim, North African Jews, Middle Eastern Jews, Ashkenazim, and Chuetas) and Majorca, as the host population of Chuetas. Genetic distances between these populations demonstrated significant differences, except between Sephardic and North African Jews, with the Chuetas as the most differentiated group, in accordance with the particular demographic history of this population. X-chromosome analysis and a comparison with autosomal data suggest a generally sex-biased demographic history in Jewish populations. Asymmetry was found between female and male effective population sizes both in the admixture processes between Jewish communities, and between them and their respective non-Jewish host populations. Results further show that these X-linked markers are highly informative for forensic purposes, and highlight the need for specific databases for differentiated Jewish populations.
报告了五个具有犹太血统的群体（西班牙系犹太人、北非犹太人、中东犹太人、德系犹太人以及胡埃塔人）和作为胡埃塔人所在宿主群体的马略卡岛人口的53个X染色体标记（32个X插入缺失、9个X-Alu插入和12个X-STR）的群体遗传数据。这些群体之间的遗传距离显示出显著差异，除了西班牙系犹太人和北非犹太人之间，胡埃塔人是差异最大的群体，这与该群体独特的人口历史相符。X染色体分析以及与常染色体数据的比较表明，犹太人群体的人口历史总体上存在性别偏差。在犹太社区之间以及它们与各自非犹太宿主群体的混合过程中，女性和男性有效群体大小之间均发现了不对称性。结果进一步表明，这些X连锁标记对于法医鉴定具有高度信息价值，并强调了为不同犹太人群体建立特定数据库的必要性。
