Susman V L, Addonizio G
Department of Psychiatry, Cornell University Medical College, New York Hospital-Westchester Division, White Plains 10605.
J Nerv Ment Dis. 1988 Apr;176(4):234-41. doi: 10.1097/00005053-198804000-00007.
Presumptive risk factors for recurrence of neuroleptic malignant syndrome (NMS) and clinical evidence for its pathogenesis are discussed. All earlier reports describing patients who have had NMS and who were either safely restarted on neuroleptic or who developed recurrence are reviewed. The authors also present their own experiences with both outcomes. Possible risk factors for recurrent NMS are administration of high-potency neuroleptics and reintroduction of neuroleptics before the initial episode of NMS has completely resolved. Bipolar disorder and concomitant use of lithium may predispose to NMS and therefore could also heighten the risk of recurrence.
本文讨论了抗精神病药恶性综合征（NMS）复发的假定危险因素及其发病机制的临床证据。回顾了所有早期报告，这些报告描述了曾患NMS且在抗精神病药治疗中安全恢复或复发的患者。作者还介绍了他们在这两种结果方面的经验。NMS复发的可能危险因素包括使用高效能抗精神病药以及在NMS初始发作完全缓解之前重新使用抗精神病药。双相情感障碍和锂盐的联合使用可能易患NMS，因此也可能增加复发风险。
