Pope H G, Cole J O, Choras P T, Fulwiler C E
J Nerv Ment Dis. 1986 Aug;174(8):493-5. doi: 10.1097/00005053-198608000-00010.
Clozapine is an antipsychotic drug reported to be virtually free of extrapyramidal effects. On the basis of this, we hypothesized that it would be unlikely to cause the neuroleptic malignant syndrome (NMS), a rare but severe reaction observed with other antipsychotic drugs. However, when we administered clozapine (in conjunction with lithium) to a patient with a past history of NMS with fluphenazine, the syndrome reappeared after about 3 weeks of treatment. This represents, to our knowledge, the first report of apparent NMS with clozapine.
氯氮平是一种据报道几乎没有锥体外系反应的抗精神病药物。基于此，我们推测它不太可能引起抗精神病药物恶性综合征（NMS），这是一种在其他抗精神病药物中观察到的罕见但严重的反应。然而，当我们给一名有使用氟奋乃静引发NMS病史的患者使用氯氮平（联合锂盐）时，该综合征在治疗约3周后再次出现。据我们所知，这是氯氮平引发明显NMS的首例报告。
