• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

使用外源性睾酮治疗男性因素不育症:尼日利亚医生的一项调查。

Use of Exogenous Testosterone for the Treatment of Male Factor Infertility: A Survey of Nigerian Doctors.

作者信息

Omisanjo Olufunmilade Akinfolarin, Ikuerowo Stephen Odunayo, Abdulsalam Moruf Adekunle, Ajenifuja Sheriff Olabode, Shittu Khadijah Adebisi

机构信息

Department of Surgery, Lagos State University College of Medicine and Teaching Hospital (LASUCOM/LASUTH), Ikeja, Lagos, Nigeria.

Department of Surgery, Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, Nigeria.

出版信息

Int J Reprod Med. 2017;2017:4607623. doi: 10.1155/2017/4607623. Epub 2017 Aug 29.

DOI:10.1155/2017/4607623
PMID:28951884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5603118/
Abstract

BACKGROUND

Though exogenous testosterone is known for its contraceptive effects in men, it is sometimes prescribed by medical practitioners for the treatment of male factor infertility in the mistaken belief that exogenous testosterone improves sperm count. The aim of this study was to evaluate the scope of testosterone use in the treatment of male factor infertility by medical practitioners in Lagos, Nigeria.

METHODS

A survey using a structured questionnaire was carried out amongst doctors attending a regular Continuing Medical Education (CME) programme in Lagos, Nigeria.

RESULTS

There were 225 respondents. Most of the respondents (69.8%, = 157) indicated that exogenous testosterone increases sperm count. Only 22 respondents (9.8%) indicated (correctly) that exogenous testosterone decreases sperm count. Seventy-seven respondents (34.2%) had prescribed some form of exogenous testosterone in the treatment of male factor infertility. The vast majority of respondents who had prescribed testosterone (81.8%, = 63) thought exogenous testosterone increases sperm count. There was no statistically significant difference in the pattern of prescription across the respondents' specialty ( = 0.859) or practice type ( = 0.747).

CONCLUSION

The misuse of exogenous testosterone for the treatment of male infertility was common amongst the respondents, with most of them wrongly believing that exogenous testosterone increases sperm count.

摘要

背景

尽管外源性睾酮因其对男性的避孕作用而为人所知,但有时医生会错误地认为外源性睾酮能提高精子数量而将其用于治疗男性因素不孕症。本研究的目的是评估尼日利亚拉各斯的医生使用睾酮治疗男性因素不孕症的情况。

方法

对参加尼日利亚拉各斯定期继续医学教育(CME)项目的医生进行了一项使用结构化问卷的调查。

结果

有225名受访者。大多数受访者(69.8%,n = 157)表示外源性睾酮会增加精子数量。只有22名受访者(9.8%)(正确地)表示外源性睾酮会降低精子数量。77名受访者(34.2%)曾开具某种形式的外源性睾酮用于治疗男性因素不孕症。绝大多数开具睾酮的受访者(81.8%,n = 63)认为外源性睾酮会增加精子数量。受访者的专业(p = 0.859)或执业类型(p = 0.747)在处方模式上没有统计学显著差异。

结论

在受访者中,滥用外源性睾酮治疗男性不孕症的情况很常见,大多数人错误地认为外源性睾酮会增加精子数量。

相似文献

1
Use of Exogenous Testosterone for the Treatment of Male Factor Infertility: A Survey of Nigerian Doctors.使用外源性睾酮治疗男性因素不育症:尼日利亚医生的一项调查。
Int J Reprod Med. 2017;2017:4607623. doi: 10.1155/2017/4607623. Epub 2017 Aug 29.
2
Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association.特发性男性不育的经验性医学治疗:美国泌尿外科学会的调查。
J Urol. 2012 Mar;187(3):973-8. doi: 10.1016/j.juro.2011.10.137. Epub 2012 Jan 20.
3
Attitude to sperm donation among medical students in Enugu, South-eastern Nigeria.尼日利亚东南部埃努古医科学生对精子捐赠的态度。
J Obstet Gynaecol. 2008 Jan;28(1):96-9. doi: 10.1080/01443610701811928.
4
Pharmacovigilance amongst doctors in private hospitals in Lagos West Senatorial District, Nigeria.尼日利亚拉各斯西区参议院选区私立医院医生的药物警戒情况。
Int J Risk Saf Med. 2011;23(4):217-26. doi: 10.3233/JRS-2011-0541.
5
Decrease in semen quality and Leydig cell function in infertile men: a longitudinal study.不育男性精液质量和莱迪希细胞功能下降:一项纵向研究。
Hum Reprod. 2018 Nov 1;33(11):1963-1974. doi: 10.1093/humrep/dey283.
6
Do men with normal testosterone-oestradiol ratios benefit from letrozole for the treatment of male infertility?正常睾酮-雌二醇比值的男性是否受益于来曲唑治疗男性不育?
Reprod Biomed Online. 2019 Jan;38(1):39-45. doi: 10.1016/j.rbmo.2018.09.016. Epub 2018 Oct 30.
7
Medical testosterone: an iatrogenic cause of male infertility and a growing problem.医用睾酮:男性不育的医源性病因且问题日益严重。
Urology. 2015 May;85(5):1068-1073. doi: 10.1016/j.urology.2014.12.052. Epub 2015 Mar 25.
8
Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. III. Higher 5 alpha-reductase activity in oligozoospermic men administered supraphysiological doses of testosterone.男性避孕研究中庚酸睾酮诱导无精子症与少精子症的比较。III. 给予超生理剂量睾酮的少精子症男性中5α-还原酶活性更高
J Clin Endocrinol Metab. 1996 Mar;81(3):902-8. doi: 10.1210/jcem.81.3.8772548.
9
Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. I: Plasma luteinizing hormone, follicle stimulating hormone, testosterone, estradiol, and inhibin concentrations.男性避孕研究中庚酸睾酮诱导无精子症与少精子症的比较。I:血浆促黄体生成素、促卵泡生成素、睾酮、雌二醇和抑制素浓度。
J Clin Endocrinol Metab. 1993 Jul;77(1):290-3. doi: 10.1210/jcem.77.1.8325955.
10
Body mass index in relation to semen quality and reproductive hormones in New Zealand men: a cross-sectional study in fertility clinics.新西兰男性的体重指数与精液质量和生殖激素的关系:生育诊所的横断面研究。
Hum Reprod. 2013 Dec;28(12):3178-87. doi: 10.1093/humrep/det379. Epub 2013 Oct 15.

本文引用的文献

1
Medical testosterone: an iatrogenic cause of male infertility and a growing problem.医用睾酮:男性不育的医源性病因且问题日益严重。
Urology. 2015 May;85(5):1068-1073. doi: 10.1016/j.urology.2014.12.052. Epub 2015 Mar 25.
2
Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception.生精作用和性腺外睾酮作用的剂量反应重叠危及激素男性避孕的原则。
FASEB J. 2014 Jun;28(6):2566-76. doi: 10.1096/fj.13-249219. Epub 2014 Mar 5.
3
Testosterone use in the male infertility population: prescribing patterns and effects on semen and hormonal parameters.男性不育人群中睾酮的应用:处方模式及对精液和激素参数的影响。
Fertil Steril. 2014 Jan;101(1):64-9. doi: 10.1016/j.fertnstert.2013.09.003. Epub 2013 Oct 2.
4
Effect of rejuvenation hormones on spermatogenesis.延缓衰老激素对精子发生的影响。
Fertil Steril. 2013 Jun;99(7):1814-20. doi: 10.1016/j.fertnstert.2013.04.003. Epub 2013 May 10.
5
Reversible infertility associated with testosterone therapy for symptomatic hypogonadism in infertile couple.与症状性性腺功能减退症的睾酮治疗相关的可逆性不孕不育,发生于不孕夫妇中。
Yonsei Med J. 2013 May 1;54(3):702-6. doi: 10.3349/ymj.2013.54.3.702.
6
Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association.特发性男性不育的经验性医学治疗:美国泌尿外科学会的调查。
J Urol. 2012 Mar;187(3):973-8. doi: 10.1016/j.juro.2011.10.137. Epub 2012 Jan 20.
7
Outcomes of clomiphene citrate treatment in young hypogonadal men.枸橼酸氯米酚治疗年轻性腺功能减退症男性的结局。
BJU Int. 2012 Aug;110(4):573-8. doi: 10.1111/j.1464-410X.2011.10702.x. Epub 2011 Nov 1.
8
Pharmacologic development of male hormonal contraceptive agents.男性激素避孕药的药理学开发。
Clin Pharmacol Ther. 2011 Jan;89(1):133-6. doi: 10.1038/clpt.2010.103. Epub 2010 Sep 8.
9
[Testosterone and infertility].[睾酮与不孕症]
Urologe A. 2010 Jan;49(1):32-6. doi: 10.1007/s00120-009-2195-x.
10
Male hormonal contraceptives.男性荷尔蒙避孕药。
Minerva Ginecol. 2006 Jun;58(3):215-26.