Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Division of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada; Faculty of Medicine, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Fertil Steril. 2014 Jan;101(1):64-9. doi: 10.1016/j.fertnstert.2013.09.003. Epub 2013 Oct 2.
To analyze how frequently and why men presenting with infertility take testosterone (T) and if negative effects of T on semen parameters are reversed following cessation.
Analysis of a prospectively collected database.
Male Infertility clinic.
PATIENT(S): Men presenting for fertility evaluation from 2008 to 2012.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The frequency and reason for T use in the infertile male population, and semen and hormonal parameters while on T and following discontinuation.
RESULT(S): A total of 59/4,400 men (1.3%) reported taking T. T was prescribed by a variety of physicians, including endocrinologists (24%), general practitioners (17%), urologists (15%), gynecologists (5%), and reproductive endocrinologists (3%). Only one of the men admitted that he had obtained T from an illicit source. More than 82% of men were prescribed T for the treatment of hypogonadism, but surprisingly, 12% (7/59) were prescribed T to treat their infertility. While on T, 88.4% of men were azoospermic, but by 6 months after T cessation, 65% of the men without other known causes for azoospermia recovered spermatogenesis.
CONCLUSION(S): In Canada, T was not commonly used by men presenting for fertility investigation (1.3%). Close to 2/3 of infertile men using T recovered spermatogenesis within 6 months of T discontinuation.
分析男性不育症患者使用睾酮（T）的频率和原因，以及 T 对精液参数的负面影响在停药后是否逆转。
前瞻性收集数据库的分析。
男性不育症诊所。
2008 年至 2012 年就诊于生育评估的男性。
无。
不育男性人群中 T 使用的频率和原因，以及 T 治疗期间和停药后精液和激素参数。
共有 59/4400 名男性（1.3%）报告使用 T。T 由各种医生开具，包括内分泌科医生（24%）、全科医生（17%）、泌尿科医生（15%）、妇科医生（5%）和生殖内分泌科医生（3%）。只有一名男性承认他从非法来源获得 T。超过 82%的男性因性腺功能减退症而开 T，但令人惊讶的是，12%（7/59）因不育而开 T。使用 T 时，88.4%的男性无精子症，但在 T 停药后 6 个月，65%无其他已知无精子症原因的男性恢复了精子发生。
在加拿大，T 并不常见于因生育问题就诊的男性（1.3%）。近 2/3 使用 T 的不育男性在 T 停药后 6 个月内恢复了精子发生。
