Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Turku PET Centre, University of Turku, Turku, Finland.
Aging Clin Exp Res. 2018 Jul;30(7):871-876. doi: 10.1007/s40520-017-0834-4. Epub 2017 Sep 26.
The p66Shc gerontogene may affect healthspan by promoting fat accumulation. We assessed changes of p66Shc-mRNA in peripheral tissues in relation to maternal obesity and the moderating effects of resistance-training (RT) exercise in elderly frail women. Thirty-seven women participated in a 4-month RT program. Twenty were offspring of lean/normal weight mothers and 17 were offspring of overweight/obese mothers (OOM). P66Shc was assessed in peripheral blood mononuclear cells (PBMC) and in subcutaneous adipose tissue (SAT) before and after RT. Overall, OOM showed elevated p66Shc mRNA levels in the PBMC. Independently from maternal obesity, following RT there was a decrease in p66Shc expression in PBMC but not in SAT, particularly in subjects with a high body mass index. Results suggest that maternal obesity has long-term effects on the expression of genes involved in mitochondrial function and fat deposition and that RT modifies p66Shc expression in PBMC with greater effects in obese subjects.ClinicalTrials.gov ID: NCT01931540.
p66Shc 可能通过促进脂肪积累来影响健康寿命。我们评估了母体肥胖与阻力训练（RT）运动对老年虚弱女性外周组织中 p66Shc-mRNA 变化的影响。37 名女性参加了为期 4 个月的 RT 项目。20 人为瘦/正常体重母亲的后代，17 人为超重/肥胖母亲（OOM）的后代。在 RT 前后评估了外周血单核细胞（PBMC）和皮下脂肪组织（SAT）中的 p66Shc。总体而言，OOM 在 PBMC 中表现出升高的 p66Shc mRNA 水平。独立于母体肥胖，RT 后 PBMC 中 p66Shc 的表达下降，但 SAT 中没有下降，尤其是在体重指数较高的受试者中。结果表明，母体肥胖对参与线粒体功能和脂肪沉积的基因表达具有长期影响，而 RT 在外周血单核细胞中改变了 p66Shc 的表达，在肥胖受试者中效果更为明显。ClinicalTrials.gov ID：NCT01931540。
