Department of Clinical Sciences, Lund University, Lund, Sweden.
Department of Intensive and Perioperative Care, Skåne University Hospital in Lund, Lund, Sweden.
Eur J Haematol. 2017 Dec;99(6):559-568. doi: 10.1111/ejh.12974. Epub 2017 Oct 16.
The aim of this study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy-induced bone marrow aplasia during the first 24 hours after platelet transfusion.
Patients admitted to the Haematology department during 7 months, and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; and Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24 hours after platelet transfusion to investigate the kinetics of platelet counts following transfusion.
Fifty-four platelet transfusion occasions in patients with chemotherapy-induced bone marrow aplasia were included. The decrease in corrected count increment (CCI) 1-24 hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1-3, the decline was 2.0% ± 0.6% (mean ± standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8% ± 1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean CCI, in the first 24 hours post-transfusion.
本研究旨在前瞻性地探讨化疗诱导的骨髓衰竭患者在血小板输注后 24 小时内血小板增加的详细纵向发展。
7 个月内入住血液科并符合纳入标准的患者分为 4 组：组 1，急性白血病患者；组 2，自体干细胞移植（SCT）后患者；组 3，异基因 SCT 后患者；组 4，干预前给予血小板输注的患者。我们在血小板输注后 24 小时内频繁采血，以研究输注后血小板计数的动力学。
共纳入 54 例化疗诱导的骨髓衰竭患者的血小板输注。所有组 1-24 小时校正计数增加（CCI）的减少可描述为线性函数。对于聚集的组 1-3 中的患者，输注后每小时下降 2.0%±0.6%（平均值±标准差）。对于组 4 的患者，CCI 的下降速度为每小时 2.8%±1.2%。我们发现，在输注后 24 小时内，无论是从血液中清除血小板的速度还是平均 CCI，各组之间均无差异。
