• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[功能性植物药环阿屯醇药理及生理活性的研究进展]

[Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity].

作者信息

Zhang Zhong-Lian, Luo Zu-Liang, Shi Hong-Wu, Zhang Li-Xia, Ma Xiao-Jun

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Jinghong 666100, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437. doi: 10.19540/j.cnki.cjcmm.20161222.066.

DOI:10.19540/j.cnki.cjcmm.20161222.066
PMID:28952245
Abstract

Cycloartenol, a phytosterol compound, also one of the key precusor substances for biosynthesis of numerous sterol compounds, has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Furthermore, cycloartenol also plays an important role in the process of plant growth and development. This article reviewed the research progress on cycloartenol pharmacological activity in domestic and foreign articles, and summarized the effect of cycloartenol and "cycloartenol pathway" on the plant growth and development, laying foundation for the its further study, development and utilization.

摘要

环阿屯醇是一种植物甾醇化合物,也是众多甾醇化合物生物合成的关键前体物质之一,具有抗炎、抗肿瘤、抗氧化、抗菌和抗阿尔茨海默病等多种药理活性。此外,环阿屯醇在植物生长发育过程中也起着重要作用。本文综述了国内外文献中环阿屯醇药理活性的研究进展,总结了环阿屯醇及“环阿屯醇途径”对植物生长发育的影响,为其进一步研究、开发和利用奠定基础。

相似文献

1
[Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity].[功能性植物药环阿屯醇药理及生理活性的研究进展]
Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(3):433-437. doi: 10.19540/j.cnki.cjcmm.20161222.066.
2
Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoeba Naegleria lovaniensis and Naegleria gruberi.通过环阿尔廷醇的甾醇生物合成以及与阿米巴原虫洛万内格里亚和格氏内格里亚光合门相关的其他生化特征。
Eur J Biochem. 1987 Apr 15;164(2):427-34. doi: 10.1111/j.1432-1033.1987.tb11075.x.
3
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis.拟南芥中通过环阿屯醇和羊毛甾醇合成植物甾醇的双重生物合成途径。
Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):725-30. doi: 10.1073/pnas.0807675106. Epub 2009 Jan 12.
4
Cloning and Functional Characterization of Cycloartenol Synthase from the Red Seaweed Laurencia dendroidea.红海藻类树状软骨藻中环阿屯醇合酶的克隆与功能表征
PLoS One. 2016 Nov 10;11(11):e0165954. doi: 10.1371/journal.pone.0165954. eCollection 2016.
5
Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design.甾醇甲基转移酶是抗变形虫治疗的靶点:向过渡态类似物和自杀底物药物设计的转变。
J Lipid Res. 2017 Dec;58(12):2310-2323. doi: 10.1194/jlr.M079418. Epub 2017 Oct 17.
6
Pathway engineering for the production of β-amyrin and cycloartenol in Escherichia coli-a method to biosynthesize plant-derived triterpene skeletons in E. coli.在大肠杆菌中生产 β-香树精和环阿屯醇的途径工程——在大肠杆菌中生物合成植物衍生三萜骨架的方法。
Appl Microbiol Biotechnol. 2017 Sep;101(17):6615-6625. doi: 10.1007/s00253-017-8409-z. Epub 2017 Jul 15.
7
Cyclobranol: a substrate for C25-methyl sterol side chains and potent mechanism-based inactivator of plant sterol methyltransferase.环戊醇:一种C25-甲基甾醇侧链的底物以及基于机制的植物甾醇甲基转移酶强效失活剂。
Bioorg Med Chem Lett. 2008 Jul 15;18(14):3878-81. doi: 10.1016/j.bmcl.2008.06.044. Epub 2008 Jun 18.
8
Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga.土壤变形虫多噬棘阿米巴通过环阿屯醇进行甾醇从头生物合成。
Biochem J. 1985 Nov 1;231(3):609-15. doi: 10.1042/bj2310609.
9
Solving the Jigsaw puzzle of phytosterol diversity by a novel sterol methyltransferase from Zea mays.通过玉米中的一种新型甾醇甲基转移酶解决植物固醇多样性难题。
J Steroid Biochem Mol Biol. 2024 Jun;240:106498. doi: 10.1016/j.jsbmb.2024.106498. Epub 2024 Mar 5.
10
2,3-Oxidosqualene cyclase and cycloartenol-s-adenosylmethionine methyltransferase activities in vivo in the cotyledon and axis tissues of germinating pea seeds.发芽豌豆种子子叶和胚轴组织中体内2,3-氧化角鲨烯环化酶和环阿屯醇-s-腺苷甲硫氨酸甲基转移酶的活性
Biochem J. 1975 Sep;150(3):323-8. doi: 10.1042/bj1500323.

引用本文的文献

1
Pharmacological Significance, Medicinal Use, and Toxicity of Extracted and Isolated Compounds from Species Found in Southern Africa: A Review.从南非发现的物种中提取和分离的化合物的药理意义、药用价值及毒性:综述
Plants (Basel). 2025 Feb 5;14(3):469. doi: 10.3390/plants14030469.
2
Metabolomics reveals changes in soil metabolic profiles during vegetation succession in karst area.代谢组学揭示了喀斯特地区植被演替过程中土壤代谢谱的变化。
Front Microbiol. 2024 Jun 26;15:1337672. doi: 10.3389/fmicb.2024.1337672. eCollection 2024.
3
Anti-Inflammatory and Antioxidant Activities of Lipophilic Fraction from Seeds Using Network Pharmacology, Molecular Docking, and In Vitro Experiments.
采用网络药理学、分子对接和体外实验研究种子脂溶性部位的抗炎和抗氧化活性。
Int J Mol Sci. 2023 Oct 6;24(19):14958. doi: 10.3390/ijms241914958.
4
Horsetail () Extract Accelerates Wound Healing in Diabetic Rats by Modulating IL-10 and MCP-1 Release and Collagen Synthesis.木贼提取物通过调节白细胞介素-10和单核细胞趋化蛋白-1的释放以及胶原蛋白合成来加速糖尿病大鼠的伤口愈合。
Pharmaceuticals (Basel). 2023 Mar 30;16(4):514. doi: 10.3390/ph16040514.
5
The network pharmacology study and molecular docking to investigate the potential mechanism of Acoritataninowii Rhizoma against Alzheimer's Disease.网络药理学研究及分子对接探讨头花蓼根茎防治阿尔茨海默病的潜在机制。
Metab Brain Dis. 2023 Aug;38(6):1937-1962. doi: 10.1007/s11011-023-01179-6. Epub 2023 Apr 10.
6
Chemical Composition and Antioxidant, Antiviral, Antifungal, Antibacterial and Anticancer Potentials of Opuntia ficus-indica Seed Oil.仙人掌籽油的化学成分及抗氧化、抗病毒、抗真菌、抗菌和抗癌活性。
Molecules. 2022 Aug 25;27(17):5453. doi: 10.3390/molecules27175453.
7
The Bioavailability and Biological Activities of Phytosterols as Modulators of Cholesterol Metabolism.植物甾醇作为胆固醇代谢调节剂的生物利用度和生物活性。
Molecules. 2022 Jan 14;27(2):523. doi: 10.3390/molecules27020523.
8
The Role of Cyclodextrins in the Design and Development of Triterpene-Based Therapeutic Agents.环糊精在基于三萜的治疗剂设计与开发中的作用。
Int J Mol Sci. 2022 Jan 10;23(2):736. doi: 10.3390/ijms23020736.
9
Antidiabetes constituents, cycloartenol and 24-methylenecycloartanol, from Ficus krishnae.从诃子 Ficus krishnae 中分离得到的抗糖尿病成分:环阿尔廷醇和 24-亚甲基环阿尔廷醇。
PLoS One. 2020 Jun 25;15(6):e0235221. doi: 10.1371/journal.pone.0235221. eCollection 2020.
10
Bioactive Phytochemicals from spp. Used in Traditional Spanish Medicine.来自用于传统西班牙医学的[物种名称]的生物活性植物化学物质。 (注:原文中“spp.”表示物种复数,这里因为不清楚具体物种,所以保留原文表述)
Plants (Basel). 2019 Jun 28;8(7):193. doi: 10.3390/plants8070193.