Department of Biology, Faculty of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt.
Molecules. 2022 Aug 25;27(17):5453. doi: 10.3390/molecules27175453.
(OFI) is a cactus that is widely cultivated in the Kingdom of Saudi Arabia especially in the Taif region due to its favorable weather for growing, and it has benefits as a food and traditional medicine. The aim of the current study was to chemically characterize seed oil from Taif, Kingdom of Saudi Arabia, using GC-MS and HPLC analysis and evaluate its antioxidant, antiviral, antifungal, antibacterial and anticancer activities. Linolenic acid was the dominating fatty acid in OFI oil, followed by oleic acid, linoleic acid, palmitic acid and stearic acid. Total tocopherol (α-, β-, Ɣ-tocopherol) was found to be 24.02 μg/mL. Campesterol was the main phytosterol, followed by γ- & β -sitosterol, and Stigmasterol. The phenolic components scored 30.5 mg gallic acid equivalent per ml of oil with 89.2% antioxidant activity (% DPPH radical inhibition) at 200 µL/mL of OFI oil. OFI oil showed an inhibition efficacy against microbial strains especially with a diameter (28.3 ± 0.4), MBC (15 µg/mL) and MIC bacteriostatic (10 µg/mL). While OFI oil had no effect against , OFI oil showed weak inhibitory activity against A-2780 (Ovarian carcinoma) cell line, although it showed significant inhibitory activity against PC-3 (Prostate carcinoma) cell line. OFI oil exhibited an antiviral effect (22.67 ± 2.79%) at 300 µg/mL of Oil against herpes simplex type 2 (HSV-2) virus. The bioactive compounds of OFI oil, as well as its main biological activities, make it a promising candidate for the non-communicable disease management.
（OFI）是一种仙人掌，由于其生长的有利天气，在沙特阿拉伯王国，特别是在塔伊夫地区广泛种植，它具有作为食物和传统药物的益处。本研究的目的是使用 GC-MS 和 HPLC 分析对来自沙特阿拉伯塔伊夫的种子油进行化学表征，并评估其抗氧化、抗病毒、抗真菌、抗菌和抗癌活性。亚油酸是 OFI 油中的主要脂肪酸，其次是油酸、亚油酸、棕榈酸和硬脂酸。总生育酚（α-、β-、γ-生育酚）含量为 24.02μg/mL。菜油甾醇是主要的植物甾醇，其次是γ-和β-谷甾醇，以及豆甾醇。酚类成分的评分是每毫升油 30.5 毫克没食子酸当量，在 200µL/mL OFI 油时具有 89.2%的抗氧化活性（% DPPH 自由基抑制率）。OFI 油对微生物菌株表现出抑制作用，特别是对 的直径（28.3±0.4）、MBC（15µg/mL）和 MIC 抑菌（10µg/mL）。虽然 OFI 油对 没有影响，但 OFI 油对 A-2780（卵巢癌）细胞系表现出微弱的抑制活性，尽管它对 PC-3（前列腺癌）细胞系表现出显著的抑制活性。OFI 油在 300µg/mL 油时对单纯疱疹病毒 2（HSV-2）病毒表现出抗病毒作用（22.67±2.79%）。OFI 油的生物活性化合物及其主要的生物活性，使它成为一种有前途的非传染性疾病管理候选物。
