Kim Seunggyu, Kim Wanho, Lim Seongjin, Jeon Jessie S
Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Korea.
Bioengineering (Basel). 2017 Jan 24;4(1):8. doi: 10.3390/bioengineering4010008.
Vascularization, the formation of new blood vessels, is an essential biological process. As the vasculature is involved in various fundamental physiological phenomena and closely related to several human diseases, it is imperative that substantial research is conducted on characterizing the vasculature and its related diseases. A significant evolution has been made to describe the vascularization process so that in vitro recapitulation of vascularization is possible. The current microfluidic systems allow elaborative research on the effects of various cues for vascularization, and furthermore, in vitro technologies have a great potential for being applied to the vascular disease models for studying pathological events and developing drug screening platforms. Here, we review methods of fabrication for microfluidic assays and inducing factors for vascularization. We also discuss applications using engineered vasculature such as in vitro vascular disease models, vasculature in organ-on-chips and drug screening platforms.
血管生成，即新血管的形成，是一个重要的生物学过程。由于脉管系统参与各种基本生理现象并与多种人类疾病密切相关，因此必须开展大量研究来表征脉管系统及其相关疾病。在描述血管生成过程方面已经取得了重大进展，从而使得在体外重现血管生成成为可能。当前的微流控系统允许对各种血管生成线索的影响进行深入研究，此外，体外技术在应用于血管疾病模型以研究病理事件和开发药物筛选平台方面具有巨大潜力。在此，我们综述了微流控分析的制造方法和血管生成的诱导因子。我们还讨论了使用工程化脉管系统的应用，如体外血管疾病模型、芯片器官中的脉管系统和药物筛选平台。
