用于药物筛选、疾病模型和组织工程的血管化微流控器官芯片。
Vascularized microfluidic organ-chips for drug screening, disease models and tissue engineering.
机构信息
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; BioSystems and Micromechanics (BioSyM), Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
出版信息
Curr Opin Biotechnol. 2018 Aug;52:116-123. doi: 10.1016/j.copbio.2018.03.011. Epub 2018 Apr 12.
Vascularization of micro-tissues in vitro has enabled formation of tissues larger than those limited by diffusion with appropriate nutrient/gas exchange as well as waste elimination. Furthermore, angiocrine signaling from the vasculature may be essential in mimicking organ-level functions in these micro-tissues. In drug screening applications, the presence of an appropriate blood-organ barrier in the form of a vasculature and its supporting cells (pericytes, appropriate stromal cells) may be essential to reproducing organ-scale drug delivery pharmacokinetics. Cutting-edge techniques including 3D bioprinting and in vitro angiogenesis and vasculogenesis could be applied to vascularize a range of tissues and organoids. Herein, we describe the latest developments in vascularization and prevascularization of micro-tissues and provide an outlook on potential future strategies.
体外微组织的血管生成使组织的形成大于受扩散限制的组织，因为具有适当的营养/气体交换以及废物清除。此外，血管中的血管生成信号对于模拟这些微组织中的器官水平功能可能是必不可少的。在药物筛选应用中，适当的血-器官屏障（以血管及其支持细胞（周细胞、适当的基质细胞）的形式）的存在对于复制器官水平的药物输送药代动力学可能是必不可少的。包括 3D 生物打印和体外血管生成和血管发生在内的前沿技术可用于使各种组织和类器官血管化。本文描述了微组织血管生成和预血管化的最新进展，并展望了潜在的未来策略。
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