Maduemem K, Vatca A, O'Neill T, Buckley D
Department of Paediatrics, Cork University Hospital, Wilton, Cork.
Ir Med J. 2017 Jun 9;110(6):586.
We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine. He presented with rash and fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder. SJS happens to be one of the rare adverse reactions of antiepilepsy drugs (AED). Management is mainly supportive with care escalation when necessary because of the significant morbidity.
我们描述了一名9岁男孩的病史，该男孩在同时使用丙戊酸和拉莫三嗪后发生了史蒂文斯-约翰逊综合征（SJS）。他在开始使用拉莫三嗪几周后出现皮疹和发热，之前因癫痫障碍一直在服用丙戊酸。SJS恰好是抗癫痫药物（AED）罕见的不良反应之一。由于其显著的发病率，治疗主要是支持性的，必要时加强护理。
