Milani Soheila, Aliakbarian Mohsen, Amouian Sakineh
From the Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Exp Clin Transplant. 2019 Oct;17(5):692-694. doi: 10.6002/ect.2016.0338. Epub 2017 Sep 26.
Liver transplant is a life-saving procedure in patients with end-stage liver disease. However, this procedure may be associated with transmission of various deficiencies of proteins synthesized by the liver. Factor I (fibrinogen) deficiency is one of the rare inherited coagulation disorders with an extremely low risk of transmission by liver transplant. We report a case of a patient with no inherited coagulation disorders but who demonstrated disturbance of fibrinogen after liver transplant. This case highlights the ever-present risk of donor-to-recipient disease transmission during transplant and emphasizes the difficulty in procuring organs from donors in which standard blood tests are insufficient to determine the likelihood of this event.
肝移植是终末期肝病患者的一种挽救生命的手术。然而，该手术可能与肝脏合成的各种蛋白质缺乏的传播有关。因子I（纤维蛋白原）缺乏是一种罕见的遗传性凝血障碍，通过肝移植传播的风险极低。我们报告一例患者，该患者无遗传性凝血障碍，但在肝移植后出现纤维蛋白原紊乱。该病例突出了移植过程中供体向受体疾病传播的持续风险，并强调了从标准血液检测不足以确定该事件可能性的供体获取器官的困难。
