Benzing Christian, Schmelzle Moritz, Oellinger Robert, Gruettner Katharina, Muehlisch Anja-Kathrin, Raschzok Nathanael, Sauer Igor, Bahra Marcus, Pratschke Johann, Guel-Klein Safak
From the Department of Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Exp Clin Transplant. 2018 Oct;16(5):568-574. doi: 10.6002/ect.2017.0108. Epub 2018 Jan 2.
Living-donor liver transplant represents an established alternative to deceased-donor liver transplant. The procedure is considered safe for donors; however, concerns about the donors' health-related quality of life and health status have not been fully addressed. Here, we aimed to assess the health-related quality of life and postoperative and 1-year clinical outcomes in living liver transplant donors.
All patients undergoing liver resection for adult-to-adult living-donor liver transplant at our center between December 1999 and March 2013 were evaluated retrospectively. Health-related quality of life was evaluated in a second assessment through written health-related quality of life questionnaires (the Short Form 36 assessment tool) sent to all patients who underwent liver resection for living-donor liver transplant between 1989 and 2012.
We identified 104 patients who underwent liver resection for living-donor liver donation between December 1999 and March 2013. Postoperative morbidity was 35.9%, with 56.8% of patients having minor complications. No postoperative, 30-day, or 90-day mortality was evident. At year 1 after transplant, 30 patients (28.8%) had (ongoing) complications, of which 80% were considered minor according to Clavien-Dindo classification. Regarding health-related quality of life, liver donors were characterized as having significantly higher scores in the general health perception component in the Short Form 36 assessment tool (P < .001). We found no significant results in other assessment components (all P > .05).
Liver donors are characterized by an excellent health-related quality of life that is comparable to the general population. Because some donors tend to have concerns regarding their employment status after the procedure, a comprehensive and critical evaluation of potential donors is needed.
活体肝移植是尸体肝移植已确立的替代方案。该手术对供体而言被认为是安全的；然而，对供体与健康相关的生活质量和健康状况的担忧尚未得到充分解决。在此，我们旨在评估活体肝移植供体与健康相关的生活质量以及术后和1年的临床结局。
对1999年12月至2013年3月期间在本中心接受成人对成人活体肝移植肝切除术的所有患者进行回顾性评估。通过向1989年至2012年间接受活体肝移植肝切除术的所有患者发送与健康相关的生活质量问卷（简短健康调查问卷36评估工具）进行第二次评估，以评估与健康相关的生活质量。
我们确定了1999年12月至2013年3月期间接受活体肝移植肝切除术的104例患者。术后发病率为35.9%，56.8%的患者有轻微并发症。无术后、30天或90天死亡率。移植后1年，30例患者（28.8%）有（持续的）并发症，根据Clavien-Dindo分类，其中80%被认为是轻微并发症。关于与健康相关的生活质量，在简短健康调查问卷36评估工具的一般健康感知部分，肝移植供体的得分显著更高（P < .001）。我们在其他评估部分未发现显著结果（所有P > .05）。
肝移植供体的特点是与健康相关的生活质量极佳，与普通人群相当。由于一些供体术后往往担心自己的就业状况，因此需要对潜在供体进行全面且严格的评估。
