Fu Zheng, Wen Donghua
Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298, USA.
Cancers (Basel). 2017 Sep 27;9(10):131. doi: 10.3390/cancers9100131.
Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays a key role in the regulation of the cell cycle. PLK1 is overexpressed in a variety of human tumors, and its expression level often correlates with increased cellular proliferation and poor prognosis in cancer patients. It has been suggested that PLK1 controls cancer development through multiple mechanisms that include canonical regulation of mitosis and cytokinesis, modulation of DNA replication, and cell survival. However, emerging evidence suggests novel and previously unanticipated roles for PLK1 during tumor development. In this review, we will summarize the recent advancements in our understanding of the oncogenic functions of PLK1, with a focus on its role in epithelial-mesenchymal transition and tumor invasion. We will further discuss the therapeutic potential of these functions.
Polo样激酶1（PLK1）是一种丝氨酸/苏氨酸激酶，在细胞周期调控中起关键作用。PLK1在多种人类肿瘤中过度表达，其表达水平通常与癌症患者细胞增殖增加和预后不良相关。有人提出，PLK1通过多种机制控制癌症发展，这些机制包括对有丝分裂和胞质分裂的经典调控、DNA复制的调节以及细胞存活。然而，新出现的证据表明PLK1在肿瘤发展过程中具有新的和以前未预料到的作用。在这篇综述中，我们将总结我们对PLK1致癌功能理解的最新进展，重点关注其在上皮-间质转化和肿瘤侵袭中的作用。我们还将进一步讨论这些功能的治疗潜力。
